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Alkynyl Benzoxazines and Dihydroquinazolines as Cysteine Targeting Covalent Warheads and Their Application in Identification of Selective Irreversible Kinase Inhibitors.
McAulay, Kirsten; Hoyt, Emily A; Thomas, Morgan; Schimpl, Marianne; Bodnarchuk, Michael S; Lewis, Hilary J; Barratt, Derek; Bhavsar, Deepa; Robinson, David M; Deery, Michael J; Ogg, Derek J; Bernardes, Gonçalo J L; Ward, Richard A; Waring, Michael J; Kettle, Jason G.
  • McAulay K; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Hoyt EA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
  • Thomas M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Schimpl M; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bodnarchuk MS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Lewis HJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Barratt D; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bhavsar D; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States.
  • Robinson DM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Deery MJ; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, U.K.
  • Ogg DJ; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Bernardes GJL; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.
  • Ward RA; Instituto de Medicina Molecular, Faculdade de Medicina de Universidad de Lisboa, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal.
  • Waring MJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.
  • Kettle JG; Northern Institute for Cancer Research, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K.
J Am Chem Soc ; 142(23): 10358-10372, 2020 06 10.
Article en En | MEDLINE | ID: mdl-32412754
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Benzoxazinas / Inhibidores de Proteínas Quinasas / Janus Quinasa 3 Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Quinazolinas / Benzoxazinas / Inhibidores de Proteínas Quinasas / Janus Quinasa 3 Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article