Development and validation of a specific and sensitive liquid chromatography tandem mass spectrometry method for determination of tetrodotoxin in human urine and its pharmacokinetic study.

Chen, Weizhu; Zhang, Yiping; Fang, Hua; Chen, Hui; He, Jianlin; Yi, Ruizao; Hong, Zhuan

Chen, Weizhu; Zhang, Yiping; Fang, Hua; Chen, Hui; He, Jianlin; Yi, Ruizao; Hong, Zhuan.

Chen W; Third Institute of Oceanography, Ministry of Natural Resource, Xiamen, China.
Zhang Y; Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Ministry of Natural Resource, Xiamen, China.
Fang H; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological, Xiamen, China.
Chen H; Third Institute of Oceanography, Ministry of Natural Resource, Xiamen, China.
He J; Engineering Research Center of Marine Biological Resource Comprehensive Utilization, Ministry of Natural Resource, Xiamen, China.
Yi R; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological, Xiamen, China.
Hong Z; Third Institute of Oceanography, Ministry of Natural Resource, Xiamen, China.

Biomed Chromatogr ; 34(9): e4900, 2020 Sep.

Article en En | MEDLINE | ID: mdl-32428255

Asunto(s)

Cromatografía Liquida/métodos; Espectrometría de Masas en Tándem/métodos; Tetrodotoxina/farmacocinética; Tetrodotoxina/orina; Humanos; Interacciones Hidrofóbicas e Hidrofílicas; Modelos Lineales; Reproducibilidad de los Resultados; Sensibilidad y Especificidad; Tetrodotoxina/química

Palabras clave

human urine pharmacokinetics, hydrophilic interaction liquid chromatography, liquid chromatography tandem mass spectrometry, tetrodotoxin

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tetrodotoxina / Cromatografía Liquida / Espectrometría de Masas en Tándem Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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