NO release regulated by doxorubicin as the green light-harvesting antenna.
Chem Commun (Camb)
; 56(47): 6332-6335, 2020 Jun 11.
Article
en En
| MEDLINE
| ID: mdl-32435776
ABSTRACT
We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Materiales Biocompatibles
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Doxorrubicina
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Luz
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Antineoplásicos
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Óxido Nítrico
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article