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NO release regulated by doxorubicin as the green light-harvesting antenna.
Fraix, Aurore; Parisi, Cristina; Failla, Mariacristina; Chegaev, Konstantin; Spyrakis, Francesca; Lazzarato, Loretta; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore.
  • Fraix A; PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy. ssortino@unict.it.
  • Parisi C; PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy. ssortino@unict.it.
  • Failla M; PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy. ssortino@unict.it and Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Chegaev K; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Spyrakis F; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Lazzarato L; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Fruttero R; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Gasco A; Department of Drug Science and Technology, University of Torino, 10125 Torino, Italy. loretta.lazzarato@unito.it.
  • Sortino S; PhotoChemLab, Department of Drug Sciences, University of Catania, 95125 Catania, Italy. ssortino@unict.it.
Chem Commun (Camb) ; 56(47): 6332-6335, 2020 Jun 11.
Article en En | MEDLINE | ID: mdl-32435776
ABSTRACT
We report for the first time a NO photodonor (NOPD) operating with the widely used chemotherapeutic agent doxorubicin (DOX) as the light-harvesting antenna. This permits NO uncaging from an N-nitroso appendage upon selective excitation of DOX with highly biocompatible green light, without precluding its typical red emission. This NOPD effectively binds DNA and photodelivers NO nearby, representing an intriguing candidate for potential multimodal therapeutic applications based on the combination of DOX and NO.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Doxorrubicina / Luz / Antineoplásicos / Óxido Nítrico Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Materiales Biocompatibles / Doxorrubicina / Luz / Antineoplásicos / Óxido Nítrico Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article