Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in <i>PTCH1</i>.

Ikemoto, Yu; Miyashita, Toshiyuki; Nasu, Michiyo; Hatsuse, Hiromi; Kajiwara, Kazuhiro; Fujii, Katsunori; Motojima, Toshino; Kokido, Ibuki; Toyoda, Masashi; Umezawa, Akihiro

Gorlin syndrome-induced pluripotent stem cells form medulloblastoma with loss of heterozygosity in PTCH1.

Ikemoto, Yu; Miyashita, Toshiyuki; Nasu, Michiyo; Hatsuse, Hiromi; Kajiwara, Kazuhiro; Fujii, Katsunori; Motojima, Toshino; Kokido, Ibuki; Toyoda, Masashi; Umezawa, Akihiro.

Ikemoto Y; Department of Reproductive Biology, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Miyashita T; Department of Molecular Genetics, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0374, Japan.
Nasu M; Department of Molecular Genetics, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0374, Japan.
Hatsuse H; Department of Reproductive Biology, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Kajiwara K; Department of Molecular Genetics, Kitasato University Graduate School of Medical Sciences, Sagamihara 252-0374, Japan.
Fujii K; Department of Reproductive Biology, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Motojima T; Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Kokido I; Department of Pediatrics, Chiba University Graduate School of Medicine, Chiba 260-8670, Japan.
Toyoda M; Department of Reproductive Biology, National Center for Child Health and Development, Tokyo 157-8535, Japan.
Umezawa A; Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan.

Aging (Albany NY) ; 12(10): 9935-9947, 2020 05 21.

Article en En | MEDLINE | ID: mdl-32436863

Asunto(s)

Síndrome del Nevo Basocelular/genética; Neoplasias Cerebelosas/genética; Pérdida de Heterocigocidad/genética; Meduloblastoma/genética; Receptor Patched-1/genética; Adolescente; Adulto; Niño; Femenino; Humanos; Células Madre Pluripotentes Inducidas; Masculino

Palabras clave

Gorlin syndrome; PTCH1; heterozygosity; induced pluripotent stem cells; medulloblastoma

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome del Nevo Basocelular / Neoplasias Cerebelosas / Pérdida de Heterocigocidad / Receptor Patched-1 / Meduloblastoma Límite: Adolescent / Adult / Child / Female / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article

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