m<sup>6</sup> A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.

Nagaki, Yushi; Motoyama, Satoru; Yamaguchi, Tomokazu; Hoshizaki, Midori; Sato, Yusuke; Sato, Teruki; Koizumi, Yukio; Wakita, Akiyuki; Kawakita, Yuta; Imai, Kazuhiro; Nanjo, Hiroshi; Watanabe, Hiroyuki; Imai, Yumiko; Minamiya, Yoshihiro; Kuba, Keiji

m⁶ A demethylase ALKBH5 promotes proliferation of esophageal squamous cell carcinoma associated with poor prognosis.

Nagaki, Yushi; Motoyama, Satoru; Yamaguchi, Tomokazu; Hoshizaki, Midori; Sato, Yusuke; Sato, Teruki; Koizumi, Yukio; Wakita, Akiyuki; Kawakita, Yuta; Imai, Kazuhiro; Nanjo, Hiroshi; Watanabe, Hiroyuki; Imai, Yumiko; Minamiya, Yoshihiro; Kuba, Keiji.

Nagaki Y; Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Akita, Japan.
Motoyama S; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Yamaguchi T; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Hoshizaki M; Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Akita, Japan.
Sato Y; Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Akita, Japan.
Sato T; Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.
Koizumi Y; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Wakita A; Department of Cardiology, Akita University Graduate School of Medicine, Akita, Japan.
Kawakita Y; Department of Biochemistry and Metabolic Science, Akita University Graduate School of Medicine, Akita, Japan.
Imai K; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Nanjo H; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Watanabe H; Department Surgery, Akita University Graduate School of Medicine, Akita, Japan.
Imai Y; Department of Pathology, Akita University Graduate School of Medicine, Akita, Japan.
Minamiya Y; Department of Cardiology, Akita University Graduate School of Medicine, Akita, Japan.
Kuba K; Laboratory of Regulation of Intractable Infectious Diseases, National Institute of Biomedical Innovation, Health and Nutrition, Osaka, Japan.

Genes Cells ; 25(8): 547-561, 2020 Aug.

Article en En | MEDLINE | ID: mdl-32449584

Asunto(s)

Desmetilasa de ARN, Homólogo 5 de AlkB/metabolismo; Carcinoma de Células Escamosas de Esófago/genética; Adenosina/análogos & derivados; Adenosina/genética; Adenosina/metabolismo; Adulto; Anciano; Enzimas AlkB/metabolismo; Desmetilasa de ARN, Homólogo 5 de AlkB/genética; Dioxigenasa FTO Dependiente de Alfa-Cetoglutarato/metabolismo; Animales; Ciclo Celular/genética; Línea Celular Tumoral; Proliferación Celular/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/genética; Inhibidor p21 de las Quinasas Dependientes de la Ciclina/metabolismo; Progresión de la Enfermedad; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/patología; Carcinoma de Células Escamosas de Esófago/metabolismo; Carcinoma de Células Escamosas de Esófago/patología; Femenino; Expresión Génica/genética; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Persona de Mediana Edad; Pronóstico; Estabilidad del ARN/genética; ARN Mensajero/genética; ARN Mensajero/metabolismo

Palabras clave

ALKBH5; ESCC; cell cycle; m6A methylation; p21

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Desmetilasa de ARN, Homólogo 5 de AlkB / Carcinoma de Células Escamosas de Esófago Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Año: 2020 Tipo del documento: Article

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