What is the optimal blood pressure level for patients with atrial fibrillation treated with direct oral anticoagulants?
J Hypertens
; 38(9): 1820-1828, 2020 09.
Article
en En
| MEDLINE
| ID: mdl-32453015
ABSTRACT
OBJECTIVE:
Limited data exist to inform blood pressure (BP) thresholds for patients with atrial fibrillation prescribed direct oral anticoagulants (DOAC) therapy in the real world setting.METHODS:
SBP was measured in 9051 primary care patients in England on DOACs for atrial fibrillation with postinitiation BP levels available within the Clinical Practice Research Datalink. The incidence rate for the primary outcome of the first recorded event (defined as a diagnosis of first stroke, recurrent stroke, myocardial infarction, symptomatic intracranial bleed, or significant gastrointestinal bleed) and of secondary outcomes all-cause mortality and cardiovascular mortality were calculated by postinitiation BP groups.RESULTS:
The Cox proportional hazard ratio of an event [crude and adjusted hazard ratio 1.04 (95% confidence interval (CI) 1.00-1.08), Pâ=â0.077 and 0.071, respectively] did not differ significantly with a 10âmmHg increase in SBP. The hazard of all-cause mortality [crude hazard ratio 0.83 (95% CI 0.80-0.86), Pâ=â0.000; adjusted hazard ratio 0.84 (95% CI 0.81-0.87), Pâ=â0.000] and cardiovascular mortality [crude hazard ratio 0.92 (95% CI 0.85-0.99), Pâ=â0.021; adjusted hazard ratio 0.93 (95% CI 0.86-1.00), Pâ=â0.041] demonstrated a significant inverse relationship with a 10âmmHg increase in SBP. Patients with a SBP within 161-210âmmHg had the lowest all-cause death rate, while patients with SBP within 121-140âmmHg had the lowest cardiovascular death rate.CONCLUSION:
SBP values below 161âmmHg are associated higher all-cause mortality, but lower event risk in patients with atrial fibrillation on DOAC therapy. The nadir SBP for lowest event rate was 120âmmHg, for lowest cardiovascular mortality was 130âmmHg and for lowest all-cause mortality was 160âmmHg. This demonstrates a need for a prospective interventional study of BP control after initiation of anticoagulation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Fibrilación Atrial
/
Presión Sanguínea
/
Inhibidores del Factor Xa
Límite:
Humans
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article