Clinical significance of gadobutrol in magnetic resonance imaging for the detection of myocardial infarction: matched-pair cohort study to compare with gadopentetate dimeglumine at standard dose.

ABSTRACT

We aimed to confirm whether gadobutrol is more useful for late gadolinium enhancement (LGE) imaging than gadopentetate dimeglumine (Gd-DTPA) at the standard dose. Patients who underwent LGE imaging to assess myocardial infarction were retrospectively enrolled gadobutrol, 51 cases; Gd-DTPA, 49 cases. Contrast ratios of infarcted lesion to remote myocardium (CRremote) and to left ventricular blood (CRblood) were compared. Patient characteristics that might affect image contrast did not differ between groups. CRremote (median, (interquartile range)) at 10 and 15 min after administration was 0.79 (0.08) and 0.70 (0.09) for gadobutrol, and 0.74 (0.13) and 0.65 (0.16) for Gd-DTPA (P < 0.05 and < 0.05), respectively. CRblood was - 0.05 (0.17) and - 0.002 (0.15) for gadobutrol, and - 0.05 (0.18) and 0.01 (0.16) for Gd-DTPA (P = 0.29 and = 0.22), respectively. Gadobutrol provided significantly better delineation of infarcted from normal myocardium than Gd-DTPA. Meanwhile, there was no difference in image contrast between infarcted myocardium and left ventricular blood.