The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by <sup>89</sup>Zr-immuno-PET in xenograft bearing mice.

Chomet, Marion; Schreurs, Maxime; Nguyen, Margaret; Howng, Bruce; Villanueva, Ruth; Krimm, Michael; Vasiljeva, Olga; van Dongen, Guus A M S; Vugts, Danielle J

The tumor targeting performance of anti-CD166 Probody drug conjugate CX-2009 and its parental derivatives as monitored by ⁸⁹Zr-immuno-PET in xenograft bearing mice.

Chomet, Marion; Schreurs, Maxime; Nguyen, Margaret; Howng, Bruce; Villanueva, Ruth; Krimm, Michael; Vasiljeva, Olga; van Dongen, Guus A M S; Vugts, Danielle J.

Chomet M; Amsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Schreurs M; Amsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Nguyen M; CytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Howng B; CytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Villanueva R; CytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Krimm M; CytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
Vasiljeva O; CytomX Therapeutics, Inc., 151 Oyster Point Blvd., Suite 400, South San Francisco, CA 94080, USA.
van Dongen GAMS; Amsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.
Vugts DJ; Amsterdam UMC, Vrije Universiteit, Dept. Radiology and Nuclear Medicine, Tracer Center Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.

Theranostics ; 10(13): 5815-5828, 2020.

Article en En | MEDLINE | ID: mdl-32483421

Asunto(s)

Molécula de Adhesión Celular del Leucocito Activado/inmunología; Maitansina/farmacología; Profármacos/farmacología; Animales; Anticuerpos Monoclonales/farmacología; Línea Celular Tumoral; Modelos Animales de Enfermedad; Femenino; Inmunoconjugados/farmacología; Neoplasias Pulmonares/tratamiento farmacológico; Ratones; Ratones Desnudos; Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos; Tomografía de Emisión de Positrones/métodos; Radioisótopos/farmacología; Radiofármacos/farmacología; Distribución Tisular/efectos de los fármacos; Circonio/química; Circonio/farmacología

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Molécula de Adhesión Celular del Leucocito Activado / Maitansina Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

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