M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133<sup>+</sup> Cancer Stem Cells and Decreasing M2 Macrophage Population.

Eom, Young Woo; Akter, Rokeya; Li, Wanlu; Lee, Suji; Hwang, Soonjae; Kim, Jiye; Cho, Mee-Yon

M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133⁺ Cancer Stem Cells and Decreasing M2 Macrophage Population.

Eom, Young Woo; Akter, Rokeya; Li, Wanlu; Lee, Suji; Hwang, Soonjae; Kim, Jiye; Cho, Mee-Yon.

Eom YW; Cell Therapy and Tissue Engineering Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Akter R; Regeneration Medicine Research Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Li W; Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Lee S; Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Hwang S; Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Kim J; Cell Therapy and Tissue Engineering Center, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.
Cho MY; Department of Plastic and Reconstructive Surgery, Yonsei University Wonju College of Medicine, Wonju, Gangwon-do 26426, Korea.

Int J Mol Sci ; 21(11)2020 May 29.

Article en En | MEDLINE | ID: mdl-32485960

Asunto(s)

Apoptosis; Neoplasias Asociadas a Colitis/metabolismo; Colitis/complicaciones; Macrófagos/metabolismo; Células Madre/metabolismo; Ligando Inductor de Apoptosis Relacionado con TNF/metabolismo; Antígeno AC133/metabolismo; Tejido Adiposo/citología; Adulto; Animales; Azoximetano; Sistemas CRISPR-Cas; Línea Celular Tumoral; Colitis/metabolismo; Neoplasias Asociadas a Colitis/complicaciones; Colon/patología; Sulfato de Dextran; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Células Madre Neoplásicas/citología

Palabras clave

CD133+ cancer stem cells; apoptosis; colitis-associated cancer; mesenchymal stem cells; tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre / Apoptosis / Colitis / Ligando Inductor de Apoptosis Relacionado con TNF / Neoplasias Asociadas a Colitis / Macrófagos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Adult / Animals / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article

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