Toll-Like Receptor 2 Promoter -196 to -174 Deletion Affects CD4 Levels Along Human Immunodeficiency Virus Infection Progression.
J Infect Dis
; 222(12): 2007-2011, 2020 11 13.
Article
en En
| MEDLINE
| ID: mdl-32516401
ABSTRACT
Toll-like receptor 2 (TLR2) plays a key role in innate immune response recognizing molecular patterns expressed by pathogens. rs111200466 is a TLR2 promoter insertion/deletion polymorphism with contradictory data about its role in human immunodeficiency virus type 1 (HIV-1) infection. We analyzed rs111200466 in HIV-1 disease progression and showed a correlation with a faster progression to the CD4+ < 200 cells/µL outcome for deletion allele carriers (Cox regression analysis:
hazard ratio, 2.4 [95% confidence interval, 1.4-4]; P = .001). When naive patients with CD4+ < 200 cells/µL started antiretroviral treatment, rs111200466-deletion carriers showed a trend toward a slower, recovery rate (time required to reach CD4+ > 350 cells/µL; Cox Pâ =â .36). Our data suggest rs111200466 as a prognosis factor for HIV-1 disease progression.Palabras clave
Texto completo:
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Banco de datos:
MEDLINE
Asunto principal:
Polimorfismo Genético
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Infecciones por VIH
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Recuento de Linfocito CD4
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Receptor Toll-Like 2
Tipo de estudio:
Clinical_trials
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Etiology_studies
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Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Female
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Humans
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Male
Idioma:
En
Año:
2020
Tipo del documento:
Article