Corynanthean-Epicatechin Flavoalkaloids from Corynanthe pachyceras.
Molecules
; 25(11)2020 Jun 07.
Article
en En
| MEDLINE
| ID: mdl-32517373
ABSTRACT
Epicatechocorynantheines A and B, and epicatechocorynantheidine were isolated from the stem bark of Corynanthe pachyceras. These molecules were pinpointed, and their isolation streamlined, by a molecular networking strategy. The structural elucidation was unambiguously accomplished from HRMS and 1D/2D NMR data. These compounds represent the first examples of corynanthean-type alkaloids tethered with a flavonoid. Epicatechocorynantheidine notably instigated two connections between the monoterpene indole alkaloid and the flavonoid, yielding an unprecedented octacyclic appendage. These flavoalkaloids exerted moderate antiplasmodial activities.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Flavonoides
/
Catequina
/
Alcaloides Indólicos
/
Antihelmínticos
Idioma:
En
Año:
2020
Tipo del documento:
Article