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Potential Preventive Strategies for Amyotrophic Lateral Sclerosis.
Kuraszkiewicz, B; Goszczynska, H; Podsiadly-Marczykowska, T; Piotrkiewicz, M; Andersen, P; Gromicho, M; Grosskreutz, J; Kuzma-Kozakiewicz, M; Petri, S; Stubbendorf, B; Szacka, K; Uysal, H; de Carvalho, M.
  • Kuraszkiewicz B; Department of Methods of Brain Imaging and Functional Research of Nervous System, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
  • Goszczynska H; Department of Methods of Brain Imaging and Functional Research of Nervous System, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
  • Podsiadly-Marczykowska T; Department of Methods of Brain Imaging and Functional Research of Nervous System, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
  • Piotrkiewicz M; Department of Methods of Brain Imaging and Functional Research of Nervous System, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw, Poland.
  • Andersen P; Department of Clinical Sciences, Umeå University, Umeå, Sweden.
  • Gromicho M; Institute of Physiology, Faculty of Medicine, University of Lisbon, Lisbon, Portugal.
  • Grosskreutz J; Department of Neurology, University Hospital Jena, Jena, Germany.
  • Kuzma-Kozakiewicz M; Jena Centre for Healthy Aging, University Hospital Jena, Jena, Germany.
  • Petri S; Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
  • Stubbendorf B; Clinic for Neurology, Hannover Medical School, Hanover, Germany.
  • Szacka K; Department of Neurology, University Hospital Jena, Jena, Germany.
  • Uysal H; Department of Neurology, Medical University of Warsaw, Warsaw, Poland.
  • de Carvalho M; Akdeniz University Faculty of Medicine, Antalya, Turkey.
Front Neurosci ; 14: 428, 2020.
Article en En | MEDLINE | ID: mdl-32528241
ABSTRACT
It may seem useless to propose preventive measures for a disease without established pathogenesis and successful therapy, such as amyotrophic lateral sclerosis (ALS). However, we will show that ALS shares essential molecular mechanisms with aging and that established anti-aging strategies, such as healthy diet or individually adjusted exercise, may be successfully applied to ameliorate the condition of ALS patients. These strategies might be applied for prevention if persons at ALS risk could be identified early enough. Recent research advances indicate that this may happen soon.
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