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Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence.
Willoughby, Jennifer L S; George, Kelly; Roberto, Mark P; Chin, Hang Gyeong; Stoiber, Patrick; Shin, Hyunjin; Pedamallu, Chandra Sekhar; Schaus, Scott E; Fitzgerald, Kevin; Shah, Jagesh; Hansen, Ulla.
  • Willoughby JLS; Alnylam Pharmaceuticals, Inc., Cambridge, MA, 02142, USA.
  • George K; Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA.
  • Roberto MP; Department of Systems Biology, Harvard Medical School, Boston, MA, 02115, USA.
  • Chin HG; Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA.
  • Stoiber P; MCBB Graduate Program, Boston University, Boston, MA, 02215, USA.
  • Shin H; New England BioLabs, Ipswich, MA, 01938, USA.
  • Pedamallu CS; Department of Biology, Boston University, 5 Cummington Mall, Boston, MA, 02215, USA.
  • Schaus SE; MCBB Graduate Program, Boston University, Boston, MA, 02215, USA.
  • Fitzgerald K; Data Science Institute, Takeda Pharmaceuticals International, Inc., Cambridge, MA, 02139, USA.
  • Shah J; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, 02142, USA.
  • Hansen U; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02115, USA.
BMC Cancer ; 20(1): 552, 2020 Jun 15.
Article en En | MEDLINE | ID: mdl-32539694
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Quinolonas / Proteínas de Unión al ADN / Benzodioxoles / Neoplasias Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Factores de Transcripción / Quinolonas / Proteínas de Unión al ADN / Benzodioxoles / Neoplasias Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article