Inclusion of family members without ME/CFS in research studies promotes discovery of biomarkers specific for ME/CFS.
Work
; 66(2): 327-337, 2020.
Article
en En
| MEDLINE
| ID: mdl-32568152
ABSTRACT
BACKGROUND:
The search for a biomarker specific for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) has been long, arduous and, to date, unsuccessful. Researchers need to consider their expenditures on each new candidate biomarker. In a previous study of antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer lymphocytes, we found lower ADCC for ME/CFS patients vs. unrelated donors but ruled against low ADCC as a biomarker because of similar ADCC for patients vs. their family members without ME/CFS.OBJECTIVE:
We applied inclusion of family members without ME/CFS, from families with multiple CFS patients, as a second non-ME/CFS control group in order to re-examine inflammation in ME/CFS.METHOD:
Total and CD16A-positive 'non-classical' anti-inflammatory monocytes were monitored.RESULTS:
Non-classical monocytes were elevated for patients vs. unrelated healthy donors but these differences were insignificant between patients vs. unaffected family members.CONCLUSIONS:
Inclusion of family members ruled against biomarker considerations for the monocytes characterized. These pilot findings for the non-classical monocytes are novel in the field of ME/CFS. We recommend that occupational therapists advocate and explain to family members without ME/CFS the need for the family members' participation as a second set of controls in pilot studies to rapidly eliminate false biomarkers, optimize patient participation, and save researchers' labor.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Relaciones Profesional-Familia
/
Biomarcadores
/
Familia
/
Síndrome de Fatiga Crónica
Tipo de estudio:
Diagnostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País como asunto:
America do norte
Idioma:
En
Año:
2020
Tipo del documento:
Article