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Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage.
Lee, Won Jin; Lee, Gyeong Hee; Hur, Jinwoo; Lee, Hyuk Gyoon; Kim, Eunsu; Won, Jun Pil; Cho, Youngjae; Choi, Mi-Jung; Seo, Han Geuk.
  • Lee WJ; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Lee GH; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Hur J; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Lee HG; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Kim E; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Won JP; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Cho Y; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Choi MJ; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
  • Seo HG; Department of Food Science and Biotechnology of Animal Resources, College of Sang-Huh Life Science, Konkuk University, 120 Neungdong-ro, Gwangjin-Gu, Seoul 05029, Korea.
Molecules ; 25(12)2020 Jun 18.
Article en En | MEDLINE | ID: mdl-32570881
ABSTRACT
This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Taurina / Corticosterona / Regulación Neoplásica de la Expresión Génica / Factor Neurotrófico Derivado del Encéfalo / Ginsenósidos / Proteínas de Neoplasias / Neuroblastoma Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Taurina / Corticosterona / Regulación Neoplásica de la Expresión Génica / Factor Neurotrófico Derivado del Encéfalo / Ginsenósidos / Proteínas de Neoplasias / Neuroblastoma Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article