Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage.
Molecules
; 25(12)2020 Jun 18.
Article
en En
| MEDLINE
| ID: mdl-32570881
ABSTRACT
This study shows that taurine and ginsenoside Rf act synergistically to increase the expression of brain-derived neurotrophic factor (BDNF) in SH-SY5Y human neuroblastoma cells in a dose- and time-dependent manner. The increase of BDNF mRNA by taurine and ginsenoside Rf was markedly attenuated by inhibitors of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release. The results from this study showed that combined treatment with both taurine and ginsenoside Rf enhanced BDNF expression and protected cells against corticosterone-induced damage.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Taurina
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Corticosterona
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Regulación Neoplásica de la Expresión Génica
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Factor Neurotrófico Derivado del Encéfalo
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Ginsenósidos
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Proteínas de Neoplasias
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Neuroblastoma
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article