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Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases.
Mormino, Elizabeth C; Toueg, Tyler N; Azevedo, Carmen; Castillo, Jessica B; Guo, Wanjia; Nadiadwala, Ayesha; Corso, Nicole K; Hall, Jacob N; Fan, Audrey; Trelle, Alexandra N; Harrison, Marc B; Hunt, Madison P; Sha, Sharon J; Deutsch, Gayle; James, Michelle; Fredericks, Carolyn A; Koran, Mary Ellen; Zeineh, Michael; Poston, Kathleen; Greicius, Michael D; Khalighi, Mehdi; Davidzon, Guido A; Shen, Bin; Zaharchuk, Greg; Wagner, Anthony D; Chin, Frederick T.
  • Mormino EC; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA. bmormino@stanford.edu.
  • Toueg TN; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Azevedo C; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Castillo JB; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Guo W; Department of Psychology, Stanford University, Stanford, CA, USA.
  • Nadiadwala A; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Corso NK; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Hall JN; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Fan A; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Trelle AN; Department of Psychology, Stanford University, Stanford, CA, USA.
  • Harrison MB; Department of Psychology, Stanford University, Stanford, CA, USA.
  • Hunt MP; Department of Psychology, Stanford University, Stanford, CA, USA.
  • Sha SJ; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Deutsch G; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • James M; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Fredericks CA; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Koran ME; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Zeineh M; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Poston K; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Greicius MD; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Khalighi M; Department of Neurology and Neurological Sciences, Stanford Medical School, 300 Pasteur Drive, Stanford, CA, 94305, USA.
  • Davidzon GA; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Shen B; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Zaharchuk G; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Wagner AD; Department of Radiology, Stanford Medical School, Stanford, CA, USA.
  • Chin FT; Department of Psychology, Stanford University, Stanford, CA, USA.
Eur J Nucl Med Mol Imaging ; 48(7): 2233-2244, 2021 07.
Article en En | MEDLINE | ID: mdl-32572562
ABSTRACT

PURPOSE:

In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer's disease (AD).

METHODS:

Forty-nine participants were scanned with 18F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aß+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined using standardized uptake value ratios (SUVRs) normalized to the inferior gray matter of the cerebellum.

RESULTS:

SUVRs in target regions were relatively stable 60 to 90 min post-injection, with the exception of very high binders who continued to show increases over time. Robust elevations in 18F-PI-2620 were observed between HC and Aß+ CI across all AD regions. Within the HC group, older age was associated with subtle elevations in target regions. Mildly elevated focal uptake was observed in the anterior temporal pole in one svPPA patient.

CONCLUSION:

Preliminary results suggest strong differences in the medial temporal lobe and cortical regions known to be impacted in AD using 18F-PI-2620 in patients along the AD trajectory. This work confirms that 18F-PI-2620 holds promise as a tool to visualize tau aggregations in AD.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer Tipo de estudio: Screening_studies Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades Neurodegenerativas / Enfermedad de Alzheimer Tipo de estudio: Screening_studies Límite: Aged / Aged80 / Humans / Middle aged Idioma: En Año: 2021 Tipo del documento: Article