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Effects of dietary stachyose levels on caecal skatole concentration, hepatic cytochrome P450 mRNA expressions and enzymatic activities in broilers.
Liu, Hai-Ying; Zhao, Xin-Yun; Yang, Gui-Qin; Liu, Ji-Zhe; Zhu, Xin.
  • Liu HY; College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang, Liaoning110866, People's Republic of China.
  • Zhao XY; College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang, Liaoning110866, People's Republic of China.
  • Yang GQ; College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang, Liaoning110866, People's Republic of China.
  • Liu JZ; College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang, Liaoning110866, People's Republic of China.
  • Zhu X; College of Animal Husbandry and Veterinary, Shenyang Agricultural University, Shenyang, Liaoning110866, People's Republic of China.
Br J Nutr ; 124(10): 1013-1020, 2020 11 28.
Article en En | MEDLINE | ID: mdl-32594918
ABSTRACT
Effects of dietary supplemental stachyose on caecal skatole concentration, hepatic cytochrome P450 (CYP450, CYP) mRNA expressions and enzymatic activities in broilers were evaluated. Arbor Acre commercial mixed male and female chicks were assigned randomly into six treatments. The positive control (PC) diet was based on maize-soyabean meal, and the negative control (NC) diet was based on maize-non-soyabean meal. The NC diet was then supplemented with 4, 5, 6 and 7 g/kg stachyose to create experimental diets, named S-4, S-5, S-6 and S-7, respectively. Each diet was fed to six replicates of ten birds from days 1 to 49. On day 49, the caecal skatole concentrations in the PC, S-4, S-5, S-6 and S-7 groups were lower than those in the NC group by 42·28, 23·68, 46·09, 15·31 and 45·14 % (P < 0·01), respectively. The lowest pH value was observed in the S-5 group (P < 0·05). The stachyose-fed groups of broilers had higher caecal acetate and propionate levels compared with control groups, and propionate levels in the S-6 and S-7 groups were higher than those in the S-4 and S-5 groups (P < 0·001). The highest CYP3A4 expression was found in the S-7 group (P < 0·05), but this was not different from PC, S-4, S-5 and S-6 treatments. There was no significant difference in CYP450 (1A2, 2D6 and 3A4) enzymatic activities among the groups (P > 0·05). In conclusion, caecal skatole levels can be influenced by dietary stachyose levels, and 5 g/kg of stachyose in the diet was suggested.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligosacáridos / Escatol / Ciego / Sistema Enzimático del Citocromo P-450 / Dieta / Hígado Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oligosacáridos / Escatol / Ciego / Sistema Enzimático del Citocromo P-450 / Dieta / Hígado Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article