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Genome-wide mapping of brain phenotypes in extended pedigrees with strong genetic loading for bipolar disorder.
Fears, Scott C; Service, Susan K; Kremeyer, Barbara; Araya, Carmen; Araya, Xinia; Bejarano, Julio; Ramirez, Margarita; Castrillón, Gabriel; Gomez-Franco, Juliana; Lopez, Maria C; Montoya, Gabriel; Montoya, Patricia; Aldana, Ileana; Teshiba, Terri M; Al-Sharif, Noor B; Jalbrzikowski, Maria; Tishler, Todd A; Escobar, Javier; Ruiz-Linares, Andrés; Lopez-Jaramillo, Carlos; Macaya, Gabriel; Molina, Julio; Reus, Victor I; Cantor, Rita M; Sabatti, Chiara; Freimer, Nelson B; Bearden, Carrie E.
  • Fears SC; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
  • Service SK; Section of Mental Health, Greater Los Angeles Veterans Administration, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
  • Kremeyer B; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA. sfears@mednet.ucla.edu.
  • Araya C; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Araya X; Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA, USA.
  • Bejarano J; Department of Genetics, Evolution and Environment, University College London, London, WC1E 6BT, UK.
  • Ramirez M; Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
  • Castrillón G; Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
  • Gomez-Franco J; Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
  • Lopez MC; Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
  • Montoya G; Insituto de Alta Tecnologìa Mèdica, Medellín, Colombia.
  • Montoya P; Department of Psychiatry, Harbor-UCLA Hospital, Los Angeles, CA, USA.
  • Aldana I; Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
  • Teshiba TM; Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
  • Al-Sharif NB; Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
  • Jalbrzikowski M; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Tishler TA; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Escobar J; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Ruiz-Linares A; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Lopez-Jaramillo C; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
  • Macaya G; Department of Psychiatry and Family Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
  • Molina J; Ministry of Education Key Laboratory of Contemporary Anthropology and Collaborative Innovation Center of Genetics and Development, School of Life Sciences and Human Phenome Institute, Fudan University, Yangpu District, Shanghai, China.
  • Reus VI; UMR 7268 ADES, CNRS, Aix-Marseille Université, EFS, Faculté de médecine Timone, Marseille, 13005, France.
  • Cantor RM; Department of Genetics, Evolution and Environment, and UCL Genetics Institute, University College London, London, WC1E 6BT, UK.
  • Sabatti C; Grupo de Investigación en Psiquiatría (Research Group in Psychiatry (GIPSI)), Departamento de Psiquiatría, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
  • Freimer NB; Cell and Molecular Biology Research Center, Universidad de Costa Rica, San Pedro de Montes de Oca, Costa Rica.
  • Bearden CE; Department of Psychiatry and Biobehavioral Science, University of California, Los Angeles, CA, USA.
Mol Psychiatry ; 26(9): 5229-5238, 2021 09.
Article en En | MEDLINE | ID: mdl-32606377
ABSTRACT
Bipolar disorder is a highly heritable illness, associated with alterations of brain structure. As such, identification of genes influencing inter-individual differences in brain morphology may help elucidate the underlying pathophysiology of bipolar disorder (BP). To identify quantitative trait loci (QTL) that contribute to phenotypic variance of brain structure, structural neuroimages were acquired from family members (n = 527) of extended pedigrees heavily loaded for bipolar disorder ascertained from genetically isolated populations in Latin America. Genome-wide linkage and association analysis were conducted on the subset of heritable brain traits that showed significant evidence of association with bipolar disorder (n = 24) to map QTL influencing regional measures of brain volume and cortical thickness. Two chromosomal regions showed significant evidence of linkage; a QTL on chromosome 1p influencing corpus callosum volume and a region on chromosome 7p linked to cortical volume. Association analysis within the two QTLs identified three SNPs correlated with the brain measures.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Trastorno Bipolar Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article