Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture.

Goldspink, Deborah A; Lu, Van B; Miedzybrodzka, Emily L; Smith, Christopher A; Foreman, Rachel E; Billing, Lawrence J; Kay, Richard G; Reimann, Frank; Gribble, Fiona M

Goldspink, Deborah A; Lu, Van B; Miedzybrodzka, Emily L; Smith, Christopher A; Foreman, Rachel E; Billing, Lawrence J; Kay, Richard G; Reimann, Frank; Gribble, Fiona M.

Goldspink DA; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Lu VB; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Miedzybrodzka EL; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Smith CA; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Foreman RE; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Billing LJ; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Kay RG; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Reimann F; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fr222@cam.ac.uk.
Gribble FM; Wellcome Trust - MRC Institute of Metabolic Science Metabolic Research Laboratories, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. Electronic address: fmg23@cam.ac.uk.

Cell Rep ; 31(13): 107833, 2020 06 30.

Article en En | MEDLINE | ID: mdl-32610134

Asunto(s)

Péptido 1 Similar al Glucagón/metabolismo; Íleon/citología; Organoides/citología; Coloración y Etiquetado; Animales; Células Cultivadas; Fenómenos Electrofisiológicos; Glucosa/metabolismo; Humanos; Células L; Ratones; Péptidos/metabolismo

Palabras clave

CRISPR-Cas9; GLP-1; L-cells; RNA sequencing; calcium; diabetes; electrophysiology; mass spectrometry; obesity; organoids

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Coloración y Etiquetado / Organoides / Péptido 1 Similar al Glucagón / Íleon Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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