A retrospective analysis of recurrent pediatric ependymoma reveals extremely poor survival and ineffectiveness of current treatments across central nervous system locations and molecular subgroups.

Ritzmann, Timothy A; Rogers, Hazel A; Paine, Simon M L; Storer, Lisa C D; Jacques, Thomas S; Chapman, Rebecca J; Ellison, David; Donson, Andrew M; Foreman, Nicholas K; Grundy, Richard G

Ritzmann, Timothy A; Rogers, Hazel A; Paine, Simon M L; Storer, Lisa C D; Jacques, Thomas S; Chapman, Rebecca J; Ellison, David; Donson, Andrew M; Foreman, Nicholas K; Grundy, Richard G.

Ritzmann TA; Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Rogers HA; Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Paine SML; Department of Neuropathology, Nottingham University Hospital, Nottingham, UK.
Storer LCD; Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Jacques TS; Developmental Biology and Cancer Programme, UCL GOS Institute of Child Health and Department of Histopathology, Great Ormond Street Hospital for Children NHS Trust, London, UK.
Chapman RJ; Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.
Ellison D; Department of Pathology, St Jude Children's Hospital, Memphis, Tennessee.
Donson AM; Department of Pediatrics, University of Colorado, Denver, Aurora, Colorado.
Foreman NK; Department of Pediatrics, University of Colorado, Denver, Aurora, Colorado.
Grundy RG; Children's Brain Tumor Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

Pediatr Blood Cancer ; 67(9): e28426, 2020 09.

Article en En | MEDLINE | ID: mdl-32614133

Asunto(s)

Neoplasias Encefálicas; Cromosomas Humanos Par 1; Metilación de ADN; ADN de Neoplasias; Ependimoma; Recurrencia Local de Neoplasia; Adolescente; Neoplasias Encefálicas/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/mortalidad; Neoplasias Encefálicas/terapia; Niño; Preescolar; Cromosomas Humanos Par 1/genética; Cromosomas Humanos Par 1/metabolismo; ADN de Neoplasias/genética; ADN de Neoplasias/metabolismo; Ependimoma/genética; Ependimoma/metabolismo; Ependimoma/mortalidad; Ependimoma/terapia; Femenino; Humanos; Lactante; Recién Nacido; Masculino; Recurrencia Local de Neoplasia/genética; Recurrencia Local de Neoplasia/metabolismo; Recurrencia Local de Neoplasia/mortalidad; Recurrencia Local de Neoplasia/terapia; Estudios Retrospectivos; Factores de Riesgo

Palabras clave

ependymoma; neuro-oncology; pediatric; radiotherapy; relapse

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Cromosomas Humanos Par 1 / Neoplasias Encefálicas / ADN de Neoplasias / Metilación de ADN / Ependimoma / Recurrencia Local de Neoplasia Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn Idioma: En Año: 2020 Tipo del documento: Article

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