Development of fluorescence polarization-based competition assay for nicotinamide N-methyltransferase.

Iyamu, Iredia D; Huang, Rong

Iyamu, Iredia D; Huang, Rong.

Iyamu ID; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, United States.
Huang R; Department of Medicinal Chemistry and Molecular Pharmacology, Center for Cancer Research, Institute for Drug Discovery, Purdue University, West Lafayette, IN, 47907, United States. Electronic address: huang-r@purdue.edu.

Anal Biochem ; 604: 113833, 2020 09 01.

Article en En | MEDLINE | ID: mdl-32622979

Asunto(s)

Técnicas Biosensibles/métodos; Inhibidores Enzimáticos; Polarización de Fluorescencia/métodos; Colorantes Fluorescentes; Nicotinamida N-Metiltransferasa/antagonistas & inhibidores; Dominio Catalítico; Inhibidores Enzimáticos/análisis; Inhibidores Enzimáticos/metabolismo; Colorantes Fluorescentes/síntesis química; Colorantes Fluorescentes/metabolismo; Ensayos Analíticos de Alto Rendimiento; Humanos; Unión Proteica

Palabras clave

Fluorescence polarization; High-throughput screening; Inhibitor; Nicotinamide N-Methyltransferase; Protein methyltransferase

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Técnicas Biosensibles / Inhibidores Enzimáticos / Nicotinamida N-Metiltransferasa / Polarización de Fluorescencia / Colorantes Fluorescentes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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