The pathogenesis of cutaneous lupus erythematosus: The aberrant distribution and function of different cell types in skin lesions.
Scand J Immunol
; 93(1): e12933, 2021 Jan.
Article
en En
| MEDLINE
| ID: mdl-32654170
ABSTRACT
Cutaneous lupus erythematosus (CLE) is an autoimmune disease with a broad range of cutaneous manifestations. In skin lesions of CLE, keratinocytes primarily undergo apoptosis. Interferon-κ(IFN-κ) is belonged to type I interferons (type I IFNs) and is selectively produced by keratinocytes. Recently, keratinocytes selectively produced IFN-κ is identified to be a key to trigger type I interferon responses in CLE. Other immune cells such as plasmacytoid dendritic cells (pDCs) are identified to be relevant origin of type I interferons (type I IFNs) which are central to the development of CLE lesions and responsible for mediating Th1 cell activity. Other types of cells such as neutrophils, B cells and Th17 cells also are involved in the development of this disease. The close interaction of those cells composes a comprehensive and complicated network in CLE. In this review, we discussed the aberrant distribution and function of different cells types involved in this disease and will offer a new direction for research and therapy in the near future.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Lupus Eritematoso Cutáneo
/
Susceptibilidad a Enfermedades
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article