Down regulating PHGDH affects the lactate production of sertoli cells in varicocele.

Guo, Wen-Bin; Huang, Zhen-Hui; Yang, Cheng; Lv, Xian-Yuan; Xia, Hui; Tian, Hu; Yang, Jian-Kun; Zhou, Qi-Zhao; Chen, Ming-Kun; Xue, Kang-Yi; Liu, Cun-Dong

Guo, Wen-Bin; Huang, Zhen-Hui; Yang, Cheng; Lv, Xian-Yuan; Xia, Hui; Tian, Hu; Yang, Jian-Kun; Zhou, Qi-Zhao; Chen, Ming-Kun; Xue, Kang-Yi; Liu, Cun-Dong.

Guo WB; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Huang ZH; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yang C; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Lv XY; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Xia H; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Tian H; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Yang JK; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Zhou QZ; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Chen MK; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Xue KY; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
Liu CD; Department of Urology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, China. cundongliu@163.com.

Reprod Biol Endocrinol ; 18(1): 70, 2020 Jul 14.

Article en En | MEDLINE | ID: mdl-32664979

Asunto(s)

Ácido Láctico/metabolismo; Fosfoglicerato-Deshidrogenasa/genética; Células de Sertoli/metabolismo; Varicocele/genética; Varicocele/metabolismo; Animales; Células Cultivadas; Regulación hacia Abajo/efectos de los fármacos; Regulación hacia Abajo/genética; Regulación Enzimológica de la Expresión Génica/efectos de los fármacos; Glucólisis/efectos de los fármacos; Glucólisis/genética; Humanos; Infertilidad Masculina/genética; Infertilidad Masculina/metabolismo; Infertilidad Masculina/patología; Masculino; Fosfoglicerato-Deshidrogenasa/antagonistas & inhibidores; Fosfoglicerato-Deshidrogenasa/metabolismo; ARN Interferente Pequeño/farmacología; Ratas; Ratas Sprague-Dawley; Células de Sertoli/efectos de los fármacos; Células de Sertoli/patología; Espermatogénesis/efectos de los fármacos; Espermatogénesis/genética; Testículo/efectos de los fármacos; Testículo/metabolismo; Testículo/patología; Varicocele/patología

Palabras clave

Glycolysis; Lactate metabolism; Phosphoglycerate dehydrogenase (PHGDH); Sertoli cells (SC); Varicocele

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células de Sertoli / Varicocele / Ácido Láctico / Fosfoglicerato-Deshidrogenasa Límite: Animals / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article

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