Morphometric Cell Classification for Single-Cell MALDI-Mass Spectrometry Imaging.
Angew Chem Int Ed Engl
; 59(40): 17447-17450, 2020 09 28.
Article
en En
| MEDLINE
| ID: mdl-32668069
ABSTRACT
The large-scale and label-free molecular characterization of single cells in their natural tissue habitat remains a major challenge in molecular biology. We present a method that integrates morphometric image analysis to delineate and classify individual cells with their single-cell-specific molecular profiles. This approach provides a new means to study spatial biological processes such as cancer field effects and the relationship between morphometric and molecular features.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Espectrometría de Masa por Láser de Matriz Asistida de Ionización Desorción
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article