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Improved Sensitivity and Reader Confidence in CT Colonography Using Dual-Layer Spectral CT: A Phantom Study.
Obmann, Markus M; An, Chansik; Schaefer, Amanda; Sun, Yuxin; Wang, Zhen J; Yee, Judy; Yeh, Benjamin M.
  • Obmann MM; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • An C; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • Schaefer A; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • Sun Y; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • Wang ZJ; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • Yee J; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
  • Yeh BM; From the Department of Radiology and Biomedical Imaging, University of California, San Francisco, 513 Parnassus Ave, San Francisco, CA 94117 (M.M.O., C.A., A.S., Y.S., Z.J.W., B.M.Y.); and Department of Radiology, Albert Einstein College of Medicine, Montefiore Medical Center, New York, NY (J.Y.).
Radiology ; 297(1): 99-107, 2020 10.
Article en En | MEDLINE | ID: mdl-32720868
ABSTRACT
Background Limited cathartic preparations for CT colonography with fecal tagging can improve patient comfort but may result in nondiagnostic examinations from poorly tagged stool. Dual-energy CT may overcome this limitation by improving the conspicuity of the contrast agent, but more data are needed. Purpose To investigate whether dual-energy CT improves polyp detection in CT colonography compared with conventional CT at different fecal tagging levels in vitro. Materials and Methods In this HIPAA-compliant study, between December 2017 and August 2019, a colon phantom 30 cm in diameter containing 60 polyps of different shapes (spherical, ellipsoid, flat) and size groups (5-9 mm, 11-15 mm) was constructed and serially filled with simulated feces tagged with four different iodine concentrations (1.26, 2.45, 4.88, and 21.00 mg of iodine per milliliter), then it was scanned with dual-energy CT with and without an outer fat ring to simulate large body size (total diameter, 42 cm). Two readers independently reviewed conventional 120-kVp CT and 40-keV monoenergetic dual-energy CT images to record the presence of polyps and confidence (three-point scale.) Generalized estimating equations were used for sensitivity comparisons between conventional CT and dual-energy CT, and a Wilcoxon signed-rank test was used for reader confidence. Results Dual-energy CT had higher overall sensitivity for polyp detection than conventional CT (58.8%; 95% confidence interval [CI] 49.7%, 67.3%; 564 of 960 polyps vs 42.1%; 95% CI 32.1%, 52.8%; 404 of 960 polyps; P < .001), including with the fat ring (48% and 31%, P < .001). Reader confidence improved with dual-energy CT compared with conventional images on all tagging levels (P < .001). Interrater agreement was substantial (κ = 0.74; 95% CI 0.70, 0.77). Conclusion Compared with conventional 120-kVp CT, dual-energy CT improved polyp detection and reader confidence in a dedicated dual-energy CT colonography phantom, especially with suboptimal fecal tagging. © RSNA, 2020.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pólipos del Colon / Colonografía Tomográfica Computarizada Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pólipos del Colon / Colonografía Tomográfica Computarizada Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article