Onabotulinumtoxin a injection with or without hydrodistension for treatment of bladder pain syndrome.
Int Urogynecol J
; 32(5): 1213-1219, 2021 May.
Article
en En
| MEDLINE
| ID: mdl-32725367
ABSTRACT
INTRODUCTION:
Onabotulinumtoxin A (BoNT-A) injection has been used for bladder pain syndrome (BPS) treatment with good results. Our aim was to assess the efficacy and safety of BoNT-A injection with or without hydrodistension (HD).METHODS:
Retrospective analysis of patients treated with BoNT-A injection with or without HD because of BPS between 2008 and 2014 in our department. One hundred U of Botox® was injected in the trigone and 100 U in the bladder wall. Follow-up included a VAS of pain (0-10), a patient satisfaction scale (0-10) and a treatment benefit scale (1-2 response to treatment; 3-4 non-response to treatment). Complications were classified according to the Clavien-Dindo (CD) classification. BoNT-A retreatment was offered at the patient's request. Reasons for non-retreatment request were collected. Postoperative outcomes were compared between BoNT-A and BoNT-A + HD.RESULTS:
Forty-one patients were included (39 females, 2 males), median age 73 years (69-78.5). Reduction in VAS, postoperative VAS = 0, satisfaction with surgery and responders to treatment were significantly higher after BoNT-A + HD (n = 26) than after BoNT-A (n = 15). Eleven (26.8%) complications (CD ≤ 2) were detected, with no differences between treatment groups. Mean follow-up was 153 (± 83) months. Twelve (46.2%) patients in the BoNT-A + HD group and seven (46.7%) patients in the BoNT-A group requested retreatment. Lack of severe pain was a common reason for treatment discontinuation.CONCLUSION:
BoNT-A injection could represent a safe and effective BPS treatment. BoNT-A + HD seems to be better than BoNT-A alone for pain relief, with no significant additional morbidity.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cistitis Intersticial
/
Toxinas Botulínicas Tipo A
Tipo de estudio:
Observational_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Año:
2021
Tipo del documento:
Article