Effectiveness of myo-inositol oxygenase in the early diagnosis of experimental acute kidney injury.
Bratisl Lek Listy
; 121(8): 565-570, 2020.
Article
en En
| MEDLINE
| ID: mdl-32726119
ABSTRACT
OBJECTIVES:
The effectiveness of the myo-inositol oxygenase (MIOX) enzyme was investigated in the diagnosis of acute kidney injury (AKI).METHODS:
In total, 40 rats were divided into 5 groups (n = 8, for each group) while left kidney ischemia-reperfusion was implemented in groups 2, 3, 4 and 5. Group 1 was the control group. Group 2 underwent 1hour ischemia and 2hour reperfusion. Group 3 underwent 1hour ischemia and 4hour reperfusion. Group 4 underwent 2hour ischemia and 2hour reperfusion. Group 5 underwent 2hour ischemia and 4hour reperfusion.RESULTS:
Serum creatinine and blood urea nitrogen levels in all ischemia-reperfusion groups were higher than in the control group (p<0.001). Serum MIOX level was higher in groups 2, 3 and 4 than in group 1 (p=0.002). Tissue MIOX level was lower in groups 2, 4, and 5 than in group 1 (p=0.039). Serum and tissue neutrophil gelatinase-associated lipocalin levels were not significantly different between the groups. The injury level in histopathologic examination was as follows group 1Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Daño por Reperfusión
/
Inositol-Oxigenasa
/
Lesión Renal Aguda
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article