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Structural analysis of the LDL receptor-interacting FERM domain in the E3 ubiquitin ligase IDOL reveals an obscured substrate-binding site.
Martinelli, Luca; Adamopoulos, Athanassios; Johansson, Patrik; Wan, Paul T; Gunnarsson, Jenny; Guo, Hongwei; Boyd, Helen; Zelcer, Noam; Sixma, Titia K.
  • Martinelli L; Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, the Netherlands.
  • Adamopoulos A; Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands.
  • Johansson P; IMED Biotech Unit, Discovery Sciences, AstraZeneca, Mölndal, Sweden.
  • Wan PT; IMED Biotech Unit, Discovery Sciences, AstraZeneca, Mölndal, Sweden.
  • Gunnarsson J; IMED Biotech Unit, Discovery Sciences, AstraZeneca, Mölndal, Sweden.
  • Guo H; IMED Biotech Unit, Discovery Sciences, AstraZeneca, Mölndal, Sweden.
  • Boyd H; IMED Biotech Unit, Discovery Sciences, AstraZeneca, Mölndal, Sweden.
  • Zelcer N; Department of Medical Biochemistry, Amsterdam UMC, Amsterdam Cardiovascular Sciences and Gastroenterology and Metabolism, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: n.zelcer@amc.uva.nl.
  • Sixma TK; Division of Biochemistry, Netherlands Cancer Institute, Amsterdam, The Netherlands; Oncode Institute, Utrecht, The Netherlands. Electronic address: t.sixma@nki.nl.
J Biol Chem ; 295(39): 13570-13583, 2020 09 25.
Article en En | MEDLINE | ID: mdl-32727844
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Ubiquitina-Proteína Ligasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptores de LDL / Ubiquitina-Proteína Ligasas Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article