Pentoxifylline and Tocopherol in the Management of Temporal Bone Osteoradionecrosis: A Case Series.
Otol Neurotol
; 41(10): 1438-1446, 2020 12.
Article
en En
| MEDLINE
| ID: mdl-32740549
ABSTRACT
OBJECTIVE:
Temporal bone osteoradionecrosis (TBORN) is a rare, chronic complication of head and neck radiation. Initial treatment consists of conservative management, with surgical resection of necrotic bone indicated for cases of severe, symptomatic, or progressive disease. Pentoxifylline-tocopherol (PENTO) has demonstrated usefulness for osteoradionecrosis of other head and neck subsites. Herein, we report five TBORN cases utilizing this protocol. STUDYDESIGN:
Retrospective case series.SETTING:
Tertiary referral center. PATIENTS This case series describes five TBORN cases in which the PENTO protocol was used in conjunction with conservative management. All patients were women and average age was 61â±â8 years. INTERVENTION All patients received a daily dose of 800âmg of pentoxifylline and 1âg of tocopherol. Four of the five patients received systemic and/or ototopical antibiotics as an antimicrobial regimen before and/or during the PENTO protocol. MAIN OUTCOMEMEASURES:
Details regarding the total duration of protocol, improvement in symptoms, exposed bone and radiographic changes, and duration until first improvement of exposed bone were collected retrospectively.RESULTS:
The average duration of PENTO protocol was 302â±â166 days. Four of the five (80%) patients demonstrated a decrease in exposed ear canal bone. Three of the five (60%) patients had stable or improvement in otologic symptoms of TBORN. One patient progressed to diffuse TBORN. The average duration until first improvement in exposed bone was 193â±â137 days.CONCLUSIONS:
The PENTO protocol may be a useful adjunct to conservative measures in the management of localized TBORN. We recommend trialing the protocol for at least 12 months.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Osteorradionecrosis
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Pentoxifilina
Tipo de estudio:
Guideline
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Observational_studies
Límite:
Aged
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Female
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Humans
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Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article