Relevance of Higher-Order Epistasis in Drug Resistance.

Lozovsky, Elena R; Daniels, Rachel F; Heffernan, Gavin D; Jacobus, David P; Hartl, Daniel L

Lozovsky, Elena R; Daniels, Rachel F; Heffernan, Gavin D; Jacobus, David P; Hartl, Daniel L.

Lozovsky ER; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.
Daniels RF; Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA.
Heffernan GD; Jacobus Pharmaceutical Company, Inc., Princeton, NJ.
Jacobus DP; Jacobus Pharmaceutical Company, Inc., Princeton, NJ.
Hartl DL; Department of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA.

Mol Biol Evol ; 38(1): 142-151, 2021 01 04.

Article en En | MEDLINE | ID: mdl-32745183

Asunto(s)

Adaptación Biológica/genética; Epistasis Genética; Antagonistas del Ácido Fólico; Plasmodium falciparum/genética; Pirimetamina; Tetrahidrofolato Deshidrogenasa/genética; Alelos; Resistencia a Medicamentos/genética; Evolución Molecular; Aptitud Genética; Plasmodium falciparum/enzimología; Saccharomyces cerevisiae

Palabras clave

Plasmodium falciparum; adaptive topography; dihydrofolate reductase; drug development; epistasis; triazine antifolates

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plasmodium falciparum / Pirimetamina / Tetrahidrofolato Deshidrogenasa / Adaptación Biológica / Epistasis Genética / Antagonistas del Ácido Fólico Idioma: En Año: 2021 Tipo del documento: Article

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