COVID-19: Pharmacology and kinetics of viral clearance.
Pharmacol Res
; 161: 105114, 2020 11.
Article
en En
| MEDLINE
| ID: mdl-32758635
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is a pandemic disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical spectrum of COVID-19 is broad and varies from mild to severe forms complicated by acute respiratory distress and death. This heterogeneity might reflect the ability of the host immune system to interact with SARS-CoV2 or the characteristics of the virus itself in terms of loads or persistence. Information on this issue might derive from interventional studies. However, results from high-quality trials are scarce. Here we evaluate the level of evidence of available published interventional studies, with a focus on randomised controlled trials and the efficacy of therapies on clinical outcomes. Moreover, we present data on a large cohort of well-characterized patients hospitalized at a single University Hospital in Milano (Italy), correlating viral clearance with clinical and biochemical features of patients.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antivirales
/
SARS-CoV-2
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COVID-19
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Tratamiento Farmacológico de COVID-19
Tipo de estudio:
Clinical_trials
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article