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The genetic architecture of human brainstem structures and their involvement in common brain disorders.
Elvsåshagen, Torbjørn; Bahrami, Shahram; van der Meer, Dennis; Agartz, Ingrid; Alnæs, Dag; Barch, Deanna M; Baur-Streubel, Ramona; Bertolino, Alessandro; Beyer, Mona K; Blasi, Giuseppe; Borgwardt, Stefan; Boye, Birgitte; Buitelaar, Jan; Bøen, Erlend; Celius, Elisabeth Gulowsen; Cervenka, Simon; Conzelmann, Annette; Coynel, David; Di Carlo, Pasquale; Djurovic, Srdjan; Eisenacher, Sarah; Espeseth, Thomas; Fatouros-Bergman, Helena; Flyckt, Lena; Franke, Barbara; Frei, Oleksandr; Gelao, Barbara; Harbo, Hanne Flinstad; Hartman, Catharina A; Håberg, Asta; Heslenfeld, Dirk; Hoekstra, Pieter J; Høgestøl, Einar A; Jonassen, Rune; Jönsson, Erik G; Kirsch, Peter; Kloszewska, Iwona; Lagerberg, Trine Vik; Landrø, Nils Inge; Le Hellard, Stephanie; Lesch, Klaus-Peter; Maglanoc, Luigi A; Malt, Ulrik F; Mecocci, Patrizia; Melle, Ingrid; Meyer-Lindenberg, Andreas; Moberget, Torgeir; Nordvik, Jan Egil; Nyberg, Lars; Connell, Kevin S O'.
  • Elvsåshagen T; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. torbjorn.elvsashagen@medisin.uio.no.
  • Bahrami S; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway. torbjorn.elvsashagen@medisin.uio.no.
  • van der Meer D; Institute of Clinical Medicine, University of Oslo, Oslo, Norway. torbjorn.elvsashagen@medisin.uio.no.
  • Agartz I; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway. shahram.bahrami@medisin.uio.no.
  • Alnæs D; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Barch DM; School of Mental Health and Neuroscience, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands.
  • Baur-Streubel R; Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.
  • Bertolino A; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
  • Beyer MK; NORMENT, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Blasi G; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Borgwardt S; Departments of Psychological & Brain Sciences, Psychiatry, and Radiology, Washington University in St. Louis, St. Louis, USA.
  • Boye B; Department of Psychology I and Centre of Mental Health, University of Würzburg, Würzburg, Germany.
  • Buitelaar J; Institute of Psychiatry, University of Bari, Bari, Italy.
  • Bøen E; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Celius EG; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Cervenka S; Division of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway.
  • Conzelmann A; Institute of Psychiatry, University of Bari, Bari, Italy.
  • Coynel D; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Di Carlo P; Department of Psychiatry (UPK), University of Basel, Basel, Switzerland.
  • Djurovic S; Institute of Psychiatry, King's College, London, UK.
  • Eisenacher S; Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
  • Espeseth T; Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Fatouros-Bergman H; Department of Behavioural Sciences in Medicine, University of Oslo, Oslo, Norway.
  • Flyckt L; Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Franke B; Karakter Child and Adolescent Psychiatry University Centre, Nijmegen, The Netherlands.
  • Frei O; Psychosomatic and CL Psychiatry, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Gelao B; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Harbo HF; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Hartman CA; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
  • Håberg A; Children and Adolescence Psychiatry, University of Tübingen, Tübingen, Germany.
  • Heslenfeld D; Transfaculty Research Platform Molecular and Cognitive Neurosciences, University of Basel, CH-4055, Basel, Switzerland.
  • Hoekstra PJ; Division of Cognitive Neuroscience, Department of Psychology, University of Basel, CH-4055 Basel, Switzerland.
  • Høgestøl EA; Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy.
  • Jonassen R; Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
  • Jönsson EG; NORMENT, Department of Clinical Science, University of Bergen, Bergen, Norway.
  • Kirsch P; Institute of Psychiatric and Psychosomatic Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  • Kloszewska I; Department of Psychology, University of Oslo, Oslo, Norway.
  • Lagerberg TV; Bjørknes College, Lovisenberggata, 13, 0456, Oslo, Norway.
  • Landrø NI; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
  • Le Hellard S; Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm Region, Stockholm, Sweden.
  • Lesch KP; Departments of Human Genetics and Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Maglanoc LA; NORMENT, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
  • Malt UF; Institute of Psychiatry, University of Bari, Bari, Italy.
  • Mecocci P; Department of Neurology, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.
  • Melle I; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
  • Meyer-Lindenberg A; Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
  • Moberget T; Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
  • Nordvik JE; Department of Radiology and Nuclear Medicine, St. Olavs Hospital, Trondheim, Norway.
  • Nyberg L; Clinical Neuropsychology section, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
  • Connell KSO; Department of Cognitive Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Nat Commun ; 11(1): 4016, 2020 08 11.
Article en En | MEDLINE | ID: mdl-32782260
ABSTRACT
Brainstem regions support vital bodily functions, yet their genetic architectures and involvement in common brain disorders remain understudied. Here, using imaging-genetics data from a discovery sample of 27,034 individuals, we identify 45 brainstem-associated genetic loci, including the first linked to midbrain, pons, and medulla oblongata volumes, and map them to 305 genes. In a replication sample of 7432 participants most of the loci show the same effect direction and are significant at a nominal threshold. We detect genetic overlap between brainstem volumes and eight psychiatric and neurological disorders. In additional clinical data from 5062 individuals with common brain disorders and 11,257 healthy controls, we observe differential volume alterations in schizophrenia, bipolar disorder, multiple sclerosis, mild cognitive impairment, dementia, and Parkinson's disease, supporting the relevance of brainstem regions and their genetic architectures in common brain disorders.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encefalopatías / Tronco Encefálico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encefalopatías / Tronco Encefálico Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article