Electromagnetic field affects the voltage-dependent potassium channel Kv1.3.
Electromagn Biol Med
; 39(4): 316-322, 2020 Oct 01.
Article
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| MEDLINE
| ID: mdl-32783480
ABSTRACT
PURPOSE:
Theoretical and experimental evidences support the hypothesis that Extremely Low-Frequency Electromagnetic Fields (ELF-EMF) can modulate voltage-gated channels. In this work we investigated the effect of ELF-EMF on Kv1.3, a member of the family of the voltage-gated potassium channels that is thought to be involved in key physiological functions, including the regulation of T-cells activation during the immune response. MATERIALS ANDMETHODS:
Kv1.3 expressing CHO-K1 cells were exposed to a 20 Hz electromagnetic field at two different intensities 268 µT and 902 µT. Kv1.3 potassium currents were recorded by whole-cell patch-clamp before, during and after field exposure.RESULTS:
We found that the Kv1.3 current was increased significantly by the ELF-EMF in a subpopulation of CHO-K1 cells. The increase developed after a few seconds from the start of exposure, reached a steady-state and took several minutes to return to the baseline after field removal.CONCLUSIONS:
These findings suggest that Kv1.3 may mediate interactions between ELF-EMF and living cells, disclosing new research opportunities on the molecular mechanisms with which electromagnetic fields affect physiological and pathological processes, including immunomodulation, inflammation and cancer.Palabras clave
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1
Banco de datos:
MEDLINE
Asunto principal:
Campos Electromagnéticos
/
Canal de Potasio Kv1.3
Límite:
Animals
Idioma:
En
Año:
2020
Tipo del documento:
Article