[Genotype Analysis of Pregnant Women with α- and ß- Thalassemia in Fuzhou Area of Fujian Province in China].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 28(4): 1303-1306, 2020 Aug.
Article
en Zh
| MEDLINE
| ID: mdl-32798416
ABSTRACT
OBJECTIVE:
To analyze the genotype of pregnant women with α- and ß- thalassemia in Fuzhou area of Fujian province in China.METHODS:
Blood routine examination and hemoglobin electrophoresis were performed for pregnant women, and positive samples were examined by gap polymerase chain reaction and reverse dot blot hybridization.RESULTS:
412 cases were diagnosed as α-thalassemia (63.9%); 201 cases were diagnosed as ß-thalassemia (31.2%); 32 cases were diagnosed as α and ß-composite thalassemia. There were 12 genotypes in α-thalassemia, whose major genotypes were --SEA/αα, α3.7/αα, -α4.2/αα and αQSα/αα, with carrying rate of 64.32%, 20.14%, 7.77% and 1.94%, respectively. There were 10 genotypes in ß- thalassemia, whose major genotypes were CD41-42/N, CD17/N, IVS-II-654/N and -28/N, with carrying rate of 30.84%, 27.86%, 15.92% and 10.45%, respectively. There were 9 genotypes in α and ß-composite thalassemia, whose major genotypes were --SEA/αα composited CD41-42/N, -α3.7/αα composited CD41-42/N, --SEA/αα composited CD17/N, with carrying rate of 18.75%, 15.62%, 15.62% respectively.CONCLUSION:
The major genotypes of pregnant women with α- and ß- thalassemia in Fuzhou area of Fujian province in China are --SEA/αα, α3.7/αα, CD41-42/N and CD17/N. Thalassemia screening and prenatal gene diagnosis should be strengthened in Fuzhou area of Fujian province in China.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Talasemia beta
/
Talasemia alfa
Límite:
Female
/
Humans
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Pregnancy
País como asunto:
Asia
Idioma:
Zh
Año:
2020
Tipo del documento:
Article