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Sex Mediates Relationships Between Regional Tau Pathology and Cognitive Decline.
Buckley, Rachel F; Scott, Matthew R; Jacobs, Heidi I L; Schultz, Aaron P; Properzi, Michael J; Amariglio, Rebecca E; Hohman, Timothy J; Mayblyum, Danielle V; Rubinstein, Zoe B; Manning, Lyssa; Hanseeuw, Bernard J; Mormino, Elizabeth C; Rentz, Dorene M; Johnson, Keith A; Sperling, Reisa A.
  • Buckley RF; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Scott MR; Brigham and Women's Hospital, Department of Neurology, Center for Alzheimer Research and Treatment, Boston, MA, USA.
  • Jacobs HIL; Melbourne School of Psychological Science, University of Melbourne, Melbourne, VIC, Australia.
  • Schultz AP; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Properzi MJ; Faculty of Health, Medicine and Life Sciences, School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, Maastricht, The Netherlands.
  • Amariglio RE; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
  • Hohman TJ; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Mayblyum DV; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Rubinstein ZB; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Manning L; Brigham and Women's Hospital, Department of Neurology, Center for Alzheimer Research and Treatment, Boston, MA, USA.
  • Hanseeuw BJ; Department of Neurology, Vanderbilt Memory and Alzheimer's Center, Vanderbilt University Medical Center, Nashville, TN, USA.
  • Mormino EC; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
  • Rentz DM; Division of Nuclear Medicine and Molecular Imaging, Department of Radiology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
  • Johnson KA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
  • Sperling RA; Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ann Neurol ; 88(5): 921-932, 2020 11.
Article en En | MEDLINE | ID: mdl-32799367
OBJECTIVE: The goal of this study was to examine sex differences in tau distribution across the brain of older adults, using positron emission tomography (PET), and investigate how these differences might associate with cognitive trajectories. METHODS: Participants were 343 clinically normal individuals (women, 58%; 73.8 [8.5] years) and 55 individuals with mild cognitive impairment (MCI; women, 38%; 76.9 [7.3] years) from the Harvard Aging Brain Study and the Alzheimer's Disease Neuroimaging Initiative. We examined 18 F-Flortaucipir (FTP)-positron emission tomography (PET) signal across 41 cortical and subcortical regions of interest (ROIs). Linear regression models estimated the effect of sex on FTP-signal for each ROI after adjusting for age and cohort. We also examined interactions between sex*Aß-PET positive / negative (+ / -) and sex*apolipoprotein ε4 (APOEε4) status. Linear mixed models estimated the moderating effect of sex on the relationship between a composite of sex-differentiated tau ROIs and cognitive decline. RESULTS: Women showed significantly higher FTP-signals than men across multiple regions of the cortical mantle (p < 0.007). ß-amyloid (Aß)-moderated sex differences in tau signal were localized to medial and inferio-lateral temporal regions (p < 0.007); Aß + women exhibited greater FTP-signal than other groups. APOEε4-moderated sex differences in FTP-signal were only found in the lateral occipital lobe. Women with higher FTP-signals in composite ROI exhibited faster cognitive decline than men (p = 0.04). INTERPRETATION: Tau vulnerability in women is not just limited to the medial temporal lobe and significantly contributed to greater risk of faster cognitive decline. Interactive effects of sex and Aß were predominantly localized in the temporal lobe, however, sex differences in extra-temporal tau highlights the possibility of accelerated tau proliferation in women with the onset of clinical symptomatology. ANN NEUROL 2020;88:921-932.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tauopatías / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tauopatías / Disfunción Cognitiva Tipo de estudio: Prognostic_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article