Physico-mechanical and finite element analysis evaluation of 3D printable alginate-methylcellulose inks for wound healing applications.
Carbohydr Polym
; 247: 116666, 2020 Nov 01.
Article
en En
| MEDLINE
| ID: mdl-32829794
ABSTRACT
The present study reports on the comprehensive physico-mechanical evaluation of 3D printable alginate-methylcellulose hydrogels with bioactive components (Manuka honey, aloe vera gel, eucalyptus essential oil) using a combined experimental-numerical approach. The 3D printable carbohydrate inks demonstrated good swelling properties under moist conditions and adequate antimicrobial and antibiofilm efficacy against both Gram positive and negative bacteria. The effect of the bioactive compounds on the viscosity and mechanical properties of the 3D printable hydrogels was assessed with rheological, nanoindentation and shear test measurements. All hydrogel compositions showed good biocompatibility on human dermal fibroblasts, stimulating cell growth as confirmed by an in vitro wound healing assay. Finite element analysis simulation was employed to further advance the calculation accuracy of the nanoindentation tests, concluding that combination of an experimental and a numerical technique may constitute a useful method to characterize the mechanical behavior of composite hydrogel films for use in wound healing applications.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cicatrización de Heridas
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Dermis
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Hidrogeles
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Alginatos
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Fibroblastos
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Impresión Tridimensional
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Metilcelulosa
Tipo de estudio:
Evaluation_studies
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article