Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C-H Di- and Trifluoromethoxylation.
Angew Chem Int Ed Engl
; 59(48): 21475-21480, 2020 11 23.
Article
en En
| MEDLINE
| ID: mdl-32830430
ABSTRACT
Applications of TEMPO. catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO. -catalyzed, redox-neutral C-H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO. /TEMPO+ redox catalytic cycle. Mechanistic studies also suggest that Li2 CO3 plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO. catalysis.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Hidrocarburos Fluorados
/
Hidrocarburos Aromáticos
Idioma:
En
Año:
2020
Tipo del documento:
Article