Your browser doesn't support javascript.
loading
Wnt Signaling in Leukemia and Its Bone Marrow Microenvironment.
Ruan, Yongsheng; Kim, Hye Na; Ogana, Heather; Kim, Yong-Mi.
  • Ruan Y; Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplantation, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA.
  • Kim HN; Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
  • Ogana H; Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplantation, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA.
  • Kim YM; Department of Pediatrics, Division of Hematology, Oncology, Blood and Marrow Transplantation, Children's Hospital Los Angeles, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90027, USA.
Int J Mol Sci ; 21(17)2020 Aug 28.
Article en En | MEDLINE | ID: mdl-32872365
ABSTRACT
Leukemia is an aggressive hematologic neoplastic disease. Therapy-resistant leukemic stem cells (LSCs) may contribute to the relapse of the disease. LSCs are thought to be protected in the leukemia microenvironment, mainly consisting of mesenchymal stem/stromal cells (MSC), endothelial cells, and osteoblasts. Canonical and noncanonical Wnt pathways play a critical role in the maintenance of normal hematopoietic stem cells (HSC) and LSCs. In this review, we summarize recent findings on the role of Wnt signaling in leukemia and its microenvironment and provide information on the currently available strategies for targeting Wnt signaling.
Asunto(s)
Palabras clave
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Leucemia / Vía de Señalización Wnt Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Células Madre Neoplásicas / Leucemia / Vía de Señalización Wnt Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article