Congenital Zika Virus Infection: a Review with Emphasis on the Spectrum of Brain Abnormalities.
Curr Neurol Neurosci Rep
; 20(11): 49, 2020 09 03.
Article
en En
| MEDLINE
| ID: mdl-32880775
ABSTRACT
PURPOSE OF REVIEW In 2016, the World Health Organization declared the Zika virus (ZIKV) outbreak a Public Health Emergency of International Concern following a cluster of associated neurological disorders and neonatal malformations. Our aim is to review the clinical and neuroimaging findings seen in congenital Zika syndrome. RECENT FINDINGS:
ZIKV injures neural progenitor cells in the hippocampus, a brain region important for learning, memory, cognition, and emotion/stress response. Positron emission tomography has revealed global neuroinflammation in ZIKV infection in animal models. Congenital Zika syndrome is associated with a spectrum of brain abnormalities, including microcephaly, parenchymal calcifications, malformations of cortical development and defective neuronal migration, corpus callosum abnormalities, ventriculomegaly, and brainstem and cerebellar abnormalities.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Complicaciones Infecciosas del Embarazo
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Virus Zika
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Infección por el Virus Zika
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Microcefalia
Tipo de estudio:
Prognostic_studies
Límite:
Female
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Humans
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Pregnancy
Idioma:
En
Año:
2020
Tipo del documento:
Article