Your browser doesn't support javascript.
loading
Tracking Cortical Changes Throughout Cognitive Decline in Parkinson's Disease.
Filippi, Massimo; Canu, Elisa; Donzuso, Giulia; Stojkovic, Tanja; Basaia, Silvia; Stankovic, Iva; Tomic, Aleksandra; Markovic, Vladana; Petrovic, Igor; Stefanova, Elka; Kostic, Vladimir S; Agosta, Federica.
  • Filippi M; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Canu E; Neurology Unit and Neurophysiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Donzuso G; Vita-Salute San Raffaele University, Milan, Italy.
  • Stojkovic T; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Basaia S; Department "G.F. Ingrassia," Section of Neurosciences, University of Catania, Catania, Italy.
  • Stankovic I; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Tomic A; Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Markovic V; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Petrovic I; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Stefanova E; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Kostic VS; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
  • Agosta F; Clinic of Neurology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia.
Mov Disord ; 35(11): 1987-1998, 2020 11.
Article en En | MEDLINE | ID: mdl-32886420
BACKGROUND: The objectives of this study were to investigate progressive cortical thinning and volume loss in Parkinson's disease (PD) patients with different longitudinal patterns of cognitive decline: with stable normal cognition, with stable mild cognitive impairment, with conversion to mild cognitive impairment, and with conversion to dementia. METHODS: We recruited 112 patients (37 Parkinson's disease with stable normal cognition, 20 Parkinson's disease with stable mild cognitive impairment, 36 Parkinson's disease with conversion to mild cognitive impairment, 19 Parkinson's disease with conversion to dementia) and 38 healthy controls. All patients underwent at least 2 visits within 4 years including clinical/cognitive assessments and structural MRI (total visits, 393). Baseline cortical thickness and gray matter volumetry were compared between groups. In PD, gray matter changes over time were investigated and compared between groups. RESULTS: At baseline, compared with Parkinson's disease with stable normal cognition cases, Parkinson's disease with conversion to mild cognitive impairment patients showed cortical atrophy of the parietal and occipital lobes, similar to Parkinson's disease with stable mild cognitive impairment and Parkinson's disease with conversion to dementia patients. The latter groups (ie, patients with cognitive impairment from the study entry) showed additional involvement of the frontotemporal cortices. No baseline volumetric differences among groups were detected. The longitudinal analysis (group-by-time interaction) showed that, versus the other patient groups, Parkinson's disease with stable mild cognitive impairment and Parkinson's disease with conversion to dementia cases accumulated the least cortical damage, with Parkinson's disease with conversion to dementia showing unique progression of right thalamic and hippocampal volume loss; Parkinson's disease with conversion to mild cognitive impairment patients showing specific cortical thinning accumulation in the medial and superior frontal gyri, inferior temporal, precuneus, posterior cingulum, and supramarginal gyri bilaterally; and Parkinson's disease with stable normal cognition patients showing cortical thinning progression, mainly in the occipital and parietal regions bilaterally. CONCLUSIONS: Cortical thinning progression is more prominent in the initial stages of PD cognitive decline. The involvement of frontotemporoparietal regions, the hippocampus, and the thalamus is associated with conversion to a more severe stage of cognitive impairment. In PD, gray matter alterations of critical brain regions may be an MRI signature for the identification of patients at risk of developing dementia. © 2020 International Parkinson and Movement Disorder Society.
Asunto(s)
Palabras clave

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedad de Parkinson / Disfunción Cognitiva Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article