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Phenome-wide Mendelian randomization mapping the influence of the plasma proteome on complex diseases.
Zheng, Jie; Haberland, Valeriia; Baird, Denis; Walker, Venexia; Haycock, Philip C; Hurle, Mark R; Gutteridge, Alex; Erola, Pau; Liu, Yi; Luo, Shan; Robinson, Jamie; Richardson, Tom G; Staley, James R; Elsworth, Benjamin; Burgess, Stephen; Sun, Benjamin B; Danesh, John; Runz, Heiko; Maranville, Joseph C; Martin, Hannah M; Yarmolinsky, James; Laurin, Charles; Holmes, Michael V; Liu, Jimmy Z; Estrada, Karol; Santos, Rita; McCarthy, Linda; Waterworth, Dawn; Nelson, Matthew R; Smith, George Davey; Butterworth, Adam S; Hemani, Gibran; Scott, Robert A; Gaunt, Tom R.
  • Zheng J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK. jie.zheng@bristol.ac.uk.
  • Haberland V; Proteome MR writing group, . jie.zheng@bristol.ac.uk.
  • Baird D; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Walker V; Proteome MR writing group.
  • Haycock PC; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Hurle MR; Proteome MR writing group.
  • Gutteridge A; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Erola P; Proteome MR writing group.
  • Liu Y; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Luo S; Proteome MR writing group.
  • Robinson J; Human Genetics, GlaxoSmithKline, Collegeville, PA, USA.
  • Richardson TG; Human Genetics, GlaxoSmithKline, Stevenage, UK.
  • Staley JR; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Elsworth B; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Burgess S; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Sun BB; School of Public Health, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, Hong Kong, China.
  • Danesh J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Runz H; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Maranville JC; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Martin HM; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Yarmolinsky J; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Laurin C; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Holmes MV; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Liu JZ; BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • Estrada K; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
  • Santos R; NIHR Blood and Transplant Research Unit in Donor Health and Genomics, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
  • McCarthy L; NIHR Cambridge Biomedical Research Centre, School of Clinical Medicine, Addenbrooke's Hospital, Cambridge, UK.
  • Waterworth D; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Hinxton, UK.
  • Nelson MR; Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
  • Smith GD; Translational Biology, Biogen, Cambridge, MA, USA.
  • Butterworth AS; Informatics and Predictive Sciences, Celgene Corporation, Cambridge, MA, USA.
  • Hemani G; School of Biological Sciences, University of Edinburgh, Edinburgh, UK.
  • Scott RA; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
  • Gaunt TR; MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Nat Genet ; 52(10): 1122-1131, 2020 10.
Article en En | MEDLINE | ID: mdl-32895551
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Predisposición Genética a la Enfermedad / Proteoma / Análisis de la Aleatorización Mendeliana Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas Sanguíneas / Predisposición Genética a la Enfermedad / Proteoma / Análisis de la Aleatorización Mendeliana Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article