Your browser doesn't support javascript.
loading
Wirelessly controlled, bioresorbable drug delivery device with active valves that exploit electrochemically triggered crevice corrosion.
Koo, Jahyun; Kim, Sung Bong; Choi, Yeon Sik; Xie, Zhaoqian; Bandodkar, Amay J; Khalifeh, Jawad; Yan, Ying; Kim, Hojun; Pezhouh, Maryam Kherad; Doty, Karen; Lee, Geumbee; Chen, Yu-Yu; Lee, Seung Min; D'Andrea, Dominic; Jung, Kimin; Lee, KunHyuck; Li, Kan; Jo, Seongbin; Wang, Heling; Kim, Jae-Hwan; Kim, Jeonghyun; Choi, Sung-Geun; Jang, Woo Jin; Oh, Yong Suk; Park, Inkyu; Kwak, Sung Soo; Park, Ji-Hyeon; Hong, Doosun; Feng, Xue; Lee, Chi-Hwan; Banks, Anthony; Leal, Cecilia; Lee, Hyuck Mo; Huang, Yonggang; Franz, Colin K; Ray, Wilson Z; MacEwan, Matthew; Kang, Seung-Kyun; Rogers, John A.
  • Koo J; School of Biomedical Engineering, Korea University, Seoul 02841, Republic of Korea.
  • Kim SB; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Choi YS; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Xie Z; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Bandodkar AJ; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Khalifeh J; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Yan Y; State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, International Research Center for Computational Mechanics, Dalian University of Technology, Dalian 116024, China.
  • Kim H; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Pezhouh MK; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Doty K; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Lee G; Department of Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
  • Chen YY; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Lee SM; Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea.
  • D'Andrea D; Feinberg School of Medicine, Northwestern University, Evanston, IL 60208, USA.
  • Jung K; Department of Comparative Biosciences Histology Service Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Lee K; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Li K; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Jo S; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Wang H; Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
  • Kim JH; Regenerative Neurorehabilitation Laboratory, Shirley Ryan Ability Lab, Chicago, IL 60611, USA.
  • Kim J; Department of Materials Science and Engineering, Korea Advanced Institute of Science Technology, Daejeon 34141, Republic of Korea.
  • Choi SG; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Jang WJ; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Oh YS; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Park I; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Kwak SS; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Park JH; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Hong D; Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Feng X; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Lee CH; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Banks A; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Leal C; Department of Electronics Convergence Engineering, Kwangwoon University, Nowon-gu, Seoul 01897, Republic of Korea.
  • Lee HM; Department of Materials Science and Engineering, Seoul National University, Seoul 08826, Republic of Korea.
  • Huang Y; Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
  • Franz CK; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
  • Ray WZ; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
  • MacEwan M; Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
  • Kang SK; Department of Materials Science Engineering, Northwestern University, Evanston, IL 60208, USA.
  • Rogers JA; Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208, USA.
Sci Adv ; 6(35): eabb1093, 2020 08.
Article en En | MEDLINE | ID: mdl-32923633
ABSTRACT
Implantable drug release platforms that offer wirelessly programmable control over pharmacokinetics have potential in advanced treatment protocols for hormone imbalances, malignant cancers, diabetic conditions, and others. We present a system with this type of functionality in which the constituent materials undergo complete bioresorption to eliminate device load from the patient after completing the final stage of the release process. Here, bioresorbable polyanhydride reservoirs store drugs in defined reservoirs without leakage until wirelessly triggered valve structures open to allow release. These valves operate through an electrochemical mechanism of geometrically accelerated corrosion induced by passage of electrical current from a wireless, bioresorbable power-harvesting unit. Evaluations in cell cultures demonstrate the efficacy of this technology for the treatment of cancerous tissues by release of the drug doxorubicin. Complete in vivo studies of platforms with multiple, independently controlled release events in live-animal models illustrate capabilities for control of blood glucose levels by timed delivery of insulin.
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Guideline Idioma: En Año: 2020 Tipo del documento: Article