Whole-Genome Sequencing of Inbred Mouse Strains Selected for High and Low Open-Field Activity.
Behav Genet
; 51(1): 68-81, 2021 01.
Article
en En
| MEDLINE
| ID: mdl-32939625
ABSTRACT
We conducted whole-genome sequencing of four inbred mouse strains initially selected for high (H1, H2) or low (L1, L2) open-field activity (OFA), and then examined strain distribution patterns for all DNA variants that differed between their BALB/cJ and C57BL/6J parental strains. Next, we assessed genome-wide sharing (3,678,826 variants) both between and within the High and Low Activity strains. Results suggested that about 10% of these DNA variants may be associated with OFA, and clearly demonstrated its polygenic nature. Finally, we conducted bioinformatic analyses of functional genomics data from mouse, rat, and human to refine previously identified quantitative trait loci (QTL) for anxiety-related measures. This combination of sequence analysis and genomic-data integration facilitated refinement of previously intractable QTL findings, and identified possible genes for functional follow-up studies.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ansiedad
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Prueba de Campo Abierto
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Ratones Endogámicos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Animals
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article