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Osimertinib, an Irreversible Next-Generation EGFR Tyrosine Kinase Inhibitor, Exerts Antitumor Activity in Various Preclinical NSCLC Models Harboring the Uncommon EGFR Mutations G719X or L861Q or S768I.
Floc'h, Nicolas; Lim, Sangbin; Bickerton, Sue; Ahmed, Afshan; Orme, Jonathan; Urosevic, Jelena; Martin, Matthew J; Cross, Darren A E; Cho, Byoung Chul; Smith, Paul D.
  • Floc'h N; AstraZeneca Oncology R&D, Research and Early Development, Bioscience, Cambridge, UK. nicolas.floch@astrazeneca.com.
  • Lim S; Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
  • Bickerton S; AstraZeneca Oncology R&D, Research and Early Development, Bioscience, Cambridge, UK.
  • Ahmed A; AstraZeneca Oncology R&D, Research and Early Development, Discovery Science, Cambridge, UK.
  • Orme J; AstraZeneca Oncology R&D, Research and Early Development, Discovery Science, Cambridge, UK.
  • Urosevic J; AstraZeneca Oncology R&D, Research and Early Development, Bioscience, Cambridge, UK.
  • Martin MJ; AstraZeneca Oncology R&D, Research and Early Development, Bioscience, Cambridge, UK.
  • Cross DAE; Global Medical Affairs, Global Medicines Development, AstraZeneca, Cambridge, UK.
  • Cho BC; Division of Medical Oncology, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea.
  • Smith PD; AstraZeneca Oncology R&D, Research and Early Development, Bioscience, Cambridge, UK.
Mol Cancer Ther ; 19(11): 2298-2307, 2020 11.
Article en En | MEDLINE | ID: mdl-32943544
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acrilamidas / Sustitución de Aminoácidos / Inhibidores de Proteínas Quinasas / Alelos / Compuestos de Anilina / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acrilamidas / Sustitución de Aminoácidos / Inhibidores de Proteínas Quinasas / Alelos / Compuestos de Anilina / Mutación Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article