Hormone References for Ultrasound Breast Staging and Endocrine Profiling to Detect Female Onset of Puberty.
J Clin Endocrinol Metab
; 105(12)2020 12 01.
Article
en En
| MEDLINE
| ID: mdl-32961560
ABSTRACT
CONTEXT Application of ultrasound (US) to evaluate attainment and morphology of glandular tissue provides a new rationale for evaluating onset and progression of female puberty, but currently no hormone references complement this method. Furthermore, previous studies have not explored the predictive value of endocrine profiling to determine female puberty onset. OBJECTIVE:
To integrate US breast staging with hypothalamic-pituitary-gonadal hormone references and test the predictive value of an endocrine profile to determine thelarche. DESIGN SETTING ANDPARTICIPANTS:
Cross-sectional sample of 601 healthy Norwegian girls, ages 6 to 16 years. MAIN OUTCOMEMEASURES:
Clinical and ultrasound breast evaluations were performed for all included girls. Blood samples were analyzed by immunoassay and ultrasensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) to quantify estradiol (E2) and estrone (E1) from the subpicomolar range.RESULTS:
References for E2, E1, luteinizing hormone, follicle-stimulating hormone, and sex hormone-binding globulin were constructed in relation to chronological age, Tanner stages, and US breast stages. An endocrine profile index score derived from principal component analysis of these analytes was a better marker of puberty onset than age or any individual hormone, with receiver-operating characteristic area under the curve 0.91 (Pâ <â 0.001). Ultrasound detection of nonpalpable glandular tissue in 14 out of 264 (5.3%) girls with clinically prepubertal presentation was associated with significantly higher median serum levels of E2 (12.5 vs 4.9 pmol/L; Pâ <â 0.05) and a distinct endocrine profile (arbitrary units; Pâ <â 0.001).CONCLUSIONS:
We provide the first hormone references for use with US breast staging and demonstrate the application of endocrine profiling to improve detection of female puberty onset.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Mama
/
Pubertad
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Hormonas Gonadales
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Técnicas de Diagnóstico Endocrino
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
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Child
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Female
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Humans
País como asunto:
Europa
Idioma:
En
Año:
2020
Tipo del documento:
Article