Dual PLK1 and STAT3 inhibition promotes glioblastoma cells apoptosis through MYC.

Wang, Hao; Tao, Zhennan; Feng, Ming; Li, Xuetao; Deng, Zhitong; Zhao, Guozheng; Yin, Haoran; Pan, Tingzheng; Chen, Guangliang; Feng, Zibin; Li, Yanyan; Zhou, Youxin

Wang, Hao; Tao, Zhennan; Feng, Ming; Li, Xuetao; Deng, Zhitong; Zhao, Guozheng; Yin, Haoran; Pan, Tingzheng; Chen, Guangliang; Feng, Zibin; Li, Yanyan; Zhou, Youxin.

Wang H; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Tao Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Feng M; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li X; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Deng Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhao G; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yin H; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Pan T; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Chen G; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Feng Z; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Li Y; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Zhou Y; Department of Neurosurgery & Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China. Electronic address: brain_lab@suda.edu.cn.

Biochem Biophys Res Commun ; 533(3): 368-375, 2020 12 10.

Article en En | MEDLINE | ID: mdl-32962858

Asunto(s)

Apoptosis/efectos de los fármacos; Neoplasias Encefálicas/genética; Proteínas de Ciclo Celular/genética; Glioblastoma/genética; Proteínas Serina-Treonina Quinasas/genética; Proteínas Proto-Oncogénicas c-myc/genética; Proteínas Proto-Oncogénicas/genética; Factor de Transcripción STAT3/genética; Animales; Antineoplásicos/farmacología; Apoptosis/genética; Neoplasias Encefálicas/metabolismo; Neoplasias Encefálicas/mortalidad; Neoplasias Encefálicas/terapia; Carcinogénesis/efectos de los fármacos; Carcinogénesis/genética; Carcinogénesis/metabolismo; Carcinogénesis/patología; Proteínas de Ciclo Celular/antagonistas & inhibidores; Proteínas de Ciclo Celular/metabolismo; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Proliferación Celular/efectos de los fármacos; Óxidos S-Cíclicos/farmacología; Femenino; Regulación Neoplásica de la Expresión Génica; Glioblastoma/metabolismo; Glioblastoma/mortalidad; Glioblastoma/terapia; Humanos; Ratones; Ratones Desnudos; Neuroglía/efectos de los fármacos; Neuroglía/metabolismo; Neuroglía/patología; Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores; Proteínas Serina-Treonina Quinasas/metabolismo; Proteínas Proto-Oncogénicas/antagonistas & inhibidores; Proteínas Proto-Oncogénicas/metabolismo; Proteínas Proto-Oncogénicas c-myc/metabolismo; Pteridinas/farmacología; ARN Interferente Pequeño/genética; ARN Interferente Pequeño/metabolismo; Factor de Transcripción STAT3/antagonistas & inhibidores; Factor de Transcripción STAT3/metabolismo; Transducción de Señal; Análisis de Supervivencia; Carga Tumoral/efectos de los fármacos; Ensayos Antitumor por Modelo de Xenoinjerto; Quinasa Tipo Polo 1

Palabras clave

Apoptosis; Glioblastoma; MYC; PLK1; STAT3

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Encefálicas / Proteínas Proto-Oncogénicas c-myc / Proteínas Proto-Oncogénicas / Proteínas Serina-Treonina Quinasas / Apoptosis / Glioblastoma / Proteínas de Ciclo Celular / Factor de Transcripción STAT3 Tipo de estudio: Prognostic_studies Idioma: En Año: 2020 Tipo del documento: Article

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