Curcumin derivative C212 inhibits Hsp90 and eliminates both growing and quiescent leukemia cells in deep dormancy.

Liu, Bi; Shen, Yunzhu; Huang, Huafang; Croce, Kimiko Della; Wu, Min; Fan, Yingjuan; Liu, Yang; Xu, Jianhua; Yao, Guang

Liu, Bi; Shen, Yunzhu; Huang, Huafang; Croce, Kimiko Della; Wu, Min; Fan, Yingjuan; Liu, Yang; Xu, Jianhua; Yao, Guang.

Liu B; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.
Shen Y; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721, USA.
Huang H; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.
Croce KD; The Second Affiliated Hospital of Fujian Medical University, Quanzhou, 362000, Fujian, China.
Wu M; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.
Fan Y; Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, 85721, USA.
Liu Y; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.
Xu J; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China.
Yao G; School of Pharmacy, Fujian Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou, 350122, China. liuyang@fjmu.edu.cn.

Cell Commun Signal ; 18(1): 159, 2020 09 29.

Article en En | MEDLINE | ID: mdl-32993709

Asunto(s)

Ciclo Celular; Curcumina/farmacología; Proteínas HSP90 de Choque Térmico/metabolismo; Leucemia/patología; Antineoplásicos/farmacología; Apoptosis/efectos de los fármacos; Ciclo Celular/efectos de los fármacos; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Fase G2/efectos de los fármacos; Proteínas HSP90 de Choque Térmico/química; Humanos; Concentración 50 Inhibidora; Mitosis/efectos de los fármacos; Agregado de Proteínas; Dominios Proteicos; Proteolisis/efectos de los fármacos

Palabras clave

Apoptosis; Curcumin derivative; Dormancy; Hsp90; Leukemia; Protein aggregation; Quiescence; Relapse

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Leucemia / Ciclo Celular / Proteínas HSP90 de Choque Térmico / Curcumina Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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