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CDK4/6 inhibition enhances antitumor efficacy of chemotherapy and immune checkpoint inhibitor combinations in preclinical models and enhances T-cell activation in patients with SCLC receiving chemotherapy.
Lai, Anne Y; Sorrentino, Jessica A; Dragnev, Konstantin H; Weiss, Jared M; Owonikoko, Taofeek K; Rytlewski, Julie A; Hood, Jill; Yang, Zhao; Malik, Rajesh K; Strum, Jay C; Roberts, Patrick J.
  • Lai AY; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA.
  • Sorrentino JA; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA jsorrentino@g1therapeutics.com.
  • Dragnev KH; Department of Hematology and Oncology, Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.
  • Weiss JM; Division of Hematology and Oncology, University of North Carolina Lineberger Comprehensive Cancer Center, Chapel Hill, North Carolina, USA.
  • Owonikoko TK; Department of Hematology and Medical Oncology, Emory University Winship Cancer Institute, Atlanta, Georgia, USA.
  • Rytlewski JA; Life Sciences Research, Adaptive Biotechnologies Corp, Seattle, Washington, USA.
  • Hood J; Life Sciences Research, Adaptive Biotechnologies Corp, Seattle, Washington, USA.
  • Yang Z; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA.
  • Malik RK; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA.
  • Strum JC; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA.
  • Roberts PJ; Research and Development, G1 Therapeutics, Inc, Research Triangle Park, North Carolina, USA.
J Immunother Cancer ; 8(2)2020 10.
Article en En | MEDLINE | ID: mdl-33004541
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Carcinoma Pulmonar de Células Pequeñas / Inhibidores de Puntos de Control Inmunológico / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Año: 2020 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activación de Linfocitos / Quinasa 4 Dependiente de la Ciclina / Quinasa 6 Dependiente de la Ciclina / Carcinoma Pulmonar de Células Pequeñas / Inhibidores de Puntos de Control Inmunológico / Neoplasias Pulmonares Límite: Animals / Female / Humans Idioma: En Año: 2020 Tipo del documento: Article