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Re-evaluating pretomanid analogues for Chagas disease: Hit-to-lead studies reveal both in vitro and in vivo trypanocidal efficacy.
Thompson, Andrew M; O'Connor, Patrick D; Marshall, Andrew J; Francisco, Amanda F; Kelly, John M; Riley, Jennifer; Read, Kevin D; Perez, Catherine J; Cornwall, Scott; Thompson, R C Andrew; Keenan, Martine; White, Karen L; Charman, Susan A; Zulfiqar, Bilal; Sykes, Melissa L; Avery, Vicky M; Chatelain, Eric; Denny, William A.
  • Thompson AM; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand. Electronic address: am.thompson@auckland.ac.nz.
  • O'Connor PD; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
  • Marshall AJ; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
  • Francisco AF; Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
  • Kelly JM; Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London, WC1E 7HT, United Kingdom.
  • Riley J; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom.
  • Read KD; Drug Discovery Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, United Kingdom.
  • Perez CJ; Department of Parasitology & Veterinary Sciences, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
  • Cornwall S; Department of Parasitology & Veterinary Sciences, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
  • Thompson RCA; Department of Parasitology & Veterinary Sciences, Murdoch University, South Street, Murdoch, Western Australia, 6150, Australia.
  • Keenan M; Epichem Pty Ltd, Suite 5, 3 Brodie-Hall Drive, Technology Park, Bentley, Western Australia, 6102, Australia.
  • White KL; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia.
  • Charman SA; Centre for Drug Candidate Optimisation, Monash University, 381 Royal Parade, Parkville, Victoria, 3052, Australia.
  • Zulfiqar B; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Queensland, 4111, Australia.
  • Sykes ML; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Queensland, 4111, Australia.
  • Avery VM; Discovery Biology, Griffith Institute for Drug Discovery, Griffith University, Don Young Road, Nathan, Queensland, 4111, Australia.
  • Chatelain E; Drugs for Neglected Diseases initiative, 15 Chemin Louis Dunant, 1202, Geneva, Switzerland.
  • Denny WA; Auckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand.
Eur J Med Chem ; 207: 112849, 2020 Dec 01.
Article en En | MEDLINE | ID: mdl-33007723
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma cruzi / Enfermedad de Chagas / Nitroimidazoles Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Search on Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Tripanocidas / Trypanosoma cruzi / Enfermedad de Chagas / Nitroimidazoles Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article