Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses.
Annu Rev Cell Dev Biol
; 36: 165-189, 2020 10 06.
Article
en En
| MEDLINE
| ID: mdl-33021824
ABSTRACT
As the world's population ages, neurodegenerative disorders are poised to become the commonest cause of death. Despite this, they remain essentially untreatable. Characterized pathologically both by the aggregation of disease-specific misfolded proteins and by changes in cellular stress responses, to date, therapeutic approaches have focused almost exclusively on reducing misfolded protein load-notably amyloid beta (Aß) in Alzheimer's disease. The repeated failure of clinical trials has led to despondency over the possibility that these disorders will ever be treated. We argue that this is in fact a time for optimism Targeting various generic stress responses is emerging as an increasingly promising means of modifying disease progression across these disorders. New treatments are approaching clinical trials, while novel means of targeting aggregates could eventually act preventively in early disease.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Estrés Fisiológico
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Enfermedades Neurodegenerativas
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Agregado de Proteínas
Límite:
Animals
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Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article